Abstract
Objectives
Few studies addressed the efficacy of human insulin regimens (mostly premix insulin) used in many low-and-middle income countries on glycemic control of children and adolescents with diabetes. The aim of this study was to assess the efficacy of the premix insulin on the glycated hemoglobin (HbA1c) in comparison to the regular with NPH insulin scheme.
Methods
A retrospective study was carried out from January 2020 to September 2022 on patients with type 1 diabetes aged below 18 years followed in Burkina Life For A Child program. They were categorized into three groups, on regular with NPH insulin (Group A), on premix insulin (Group B) and on regular with premix insulin (Group C). Outcome was analyzed based on HbA1c level.
Results
Sixty-eight patients with a mean age of 15.38 ± 2.26 years and the sex ratio (M/W) 0.94 were studied. There were 14 in Group A, 20 in Group B, and 34 patients in Group C. The mean HbA1c value in the corresponding insulin regimen was 12.8 ± 1.39%, 9.87 ± 2.18%, and 10.66 ± 2.1%, respectively. Glycemic control was better in Groups B and C than Group A (p<0.05) but there was no difference between groups B and C.
Conclusions
Our results indicate that the use of premix insulin gives a better glycemic control than NPH insulin. However, further prospective study of these insulin regimens with a strengthening education strategy and glycemic control by continuous glucose monitoring and HbA1c is required to corroborate these preliminary findings.
Acknowledgments
We are thankful to LFAC (Life For A Child) for their immense support to these patients with type 1 diabetes.
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Research funding: None declared.
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Author contributions: Conceptualization, YS, OG, MSO and YJD; validation, OG, CGK and YJD; acquisition of data, YS, WPAHB, RB, AI and NCS; investigation, YS, WPAHB, RB, AI; formal analysis, YS; data curation, YS; writing—original draft preparation, YS; writing—review and editing, YS and WPAHB; supervision, NCS, OG, CGK, MSO and YJD. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Conflicts of interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: The local Institutional Review Board deemed the study exempt from review.
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