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Licensed Unlicensed Requires Authentication Published by De Gruyter January 10, 2022

Neuroprotective potential of Celastrus paniculatus seeds against common neurological ailments: a narrative review

  • Divya Sankaramourthy ORCID logo EMAIL logo , Lakshmi Sankaranarayanan ORCID logo , Kavimani Subramanian ORCID logo and Sudha Rani Sadras ORCID logo

Abstract

The most common human neurodegenerative diseases like Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) etc. have been recognized to result from a complex interplay between genetic predisposition and defective cellular dynamics such as inappropriate accumulation of unfolded proteins, oxygen free radicals and mitochondrial dysfunction. The treatment strategies available today for these neurodegenerative ailments are only palliative and are incapable of restraining the progression of the disease. Hence, there is an immense requirement for identification of drug candidates with the ability to alleviate neuronal damage along with controlling progression of the disease. From time immemorial mankind has been relying on plants for treating varied types of dreadful diseases. Among the various medicinal plants used for treating various neurological ailments, Celastrus paniculatus (CP) popularly known as Jyotishmati or Malkangni is well known in the Ayurveda system of Indian Traditional Medicine whose seeds and seed oil have been used for centuries in treating epilepsy, dementia, facial paralysis, amnesia, anxiety, sciatica, cognitive dysfunctions etc. This review apart from specifying the phytochemical characteristics and traditional uses of C. paniculatus seeds and seed oil also exemplify the comprehensive data derived from various research reports on their therapeutic potential against some common neurological disorders.


Corresponding author: Divya Sankaramourthy, Ph.D Scholar, Department of Pharmacology, Mother Theresa Post Graduate and Research Institute of Health Sciences (affiliated to Pondicherry University), Indira Nagar, Gorimedu, Puducherry, 605006, India, E-mail:

  1. Research funding: No funding has been involved.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. All authors have contributed equally to the conception of topic, interpretation and correlation of available literature evidence for the preparation of this review article.

  3. Competing interests: All authors manifest that there are no conflict of interests.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable (no human participants, human data or human tissue involved).

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Received: 2021-10-01
Accepted: 2021-12-28
Published Online: 2022-01-10

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