Abstract
Background
Hasat-ul Kilya (Nephrolithiasis) is one of the most common chronic conditions and has been known to the mankind since antiquity. The incidence is increasing globally with geographic, racial and gender variation in its occurrence. Medical management of Nephrolithiasis still poses a considerable challenge for modern medical practice. Unani drugs possessing lithotriptic activity are not only cost effective but also have least side effects. Safūf Hajar-al Yahūd has been used since long for the treatment of Hasat-ul Kilya (Nephrolithiasis) but no documentary evidence based on scientific parameters as to its safety and efficacy are available.
Objective
To validate the safety and efficacy of Safūf Hajar-al Yahūd in the treatment of Hasat-ul Kilya.
Methodology
An open prospective clinical trial was carried out on 107 subjects of renal calculi of 3–7 mm diameter diagnosed by Ultrasonogram-KUB (USG-KUB). Subjects were evaluated by clinical history & examination, laboratory investigations followed by USG-KUB for confirmation. The safety was assessed by reporting of adverse events and by pathological and biochemical investigations. Assessment of efficacy was based on improvement observed in VAS score and expulsion/reduction of stone size as detected by USG-KUB.
Results
Substantial reduction (53%) in the size of calculi confirmed by USG-KUB and considerable lowering of VAS score (75%) were observed with the active intervention in majority of the cases
Conclusion
The trial has revealed that the Unani pharmacopoeal formulation Safūf Hajar-al Yahūd was well tolerated and has the therapeutic potential in the reduction and expulsion of renal calculi.
Funding source: Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy
Acknowledgements
The authors are grateful to the M/o AYUSH, Govt of India for sponsoring and allotting the study to R.R.I.U.M, Chennai. The authors also duly acknowledge the contribution of a team of C.C.R.U.M Officers for their role in study protocol preparation. The authors also duly acknowledge Dr. Sheila Sathiya Kumar, Sonologist, Hibeam Scans, Roypuram, Chennai for their valuable contribution.
Research funding: The study has been entirely funded by Central Council for Research in Unani Medicine (CCRUM), New Delhi, Ministry of AYUSH, Government of India.
Author contributions: All the authors have accepted the responsibility for the entire content of the submitted manuscript and approved submission.
Competing interests: Funding organization played no role in the study design, in the collection, analysis and interpretation of data, in the writing of report or in the decision to submit the report for publication.
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