Abstract
Background
Exposure to organic solvents (OS) adversely affects different body systems, the central and peripheral nervous systems being the most susceptible ones.
Objectives
This study investigated the role of iron in association with some neurotransmitters for diagnosis of neurotoxicity of OS.
Methods
The study included 90 workers, 50 occupationally exposed to OS and 40 representing control group. Blood samples were collected from the included subjects for determination of serum iron, total iron binding capacity (TIBC), serotonin and gamma-aminobutyric acid (GABA).
Results
Revealed reduction in serotonin level and serum iron. However, the elevation in GABA and TIBC was observed. The duration of exposure was significantly correlated with iron and serotonin while it was positively correlated with GABA and TIBC.
Conclusions
Elevated GABA and TIBC with decreased serotonin and serum iron can be used as early diagnostic measures to detect the neurotoxic effects of OS.
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Research funding: The author(s) received financial support for the research from National Research Centre.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Ethical statement: Approval of the ethics committee at the National Research Centre was taken prior to the study (registration number 15178). Written Consent was obtained from each participant in the current study.
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