Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter June 20, 2023

The role of psychiatry in diagnosis and treatment of paediatric chronic fatigue syndrome – a scoping literature review

  • Reinhard Dolp , David PR Wardle ORCID logo EMAIL logo and Sarosh Khalid-Khan

Abstract

Objectives

Paediatric Chronic Fatigue Syndrome (pCFS) is a common condition that significantly disrupts a healthy psychosocial development. Psychiatric symptoms associated with pCFS are conceptualized as either part of its complex etiology, its consequence, or as a comorbidity. However, patients with this condition are rarely seen by psychiatrists. This scoping review aims to explore the role of psychiatry in the diagnosis and treatment of pCFS.

Content

A scoping review of literature was conducted using MEDLINE, EMBASE, Cochrane and PsycINFO. Databases were searched for articles describing psychiatric involvement in the diagnosis or treatment of children and adolescents (age ≤ 18) with pCFS. A grey literature search was also conducted to identify additional guidelines and national recommendations to identify the role of psychiatry in the diagnosis and treatment of pCFS.

Summary

The search provided 436 articles of which 16 met inclusion criteria. Grey literature search identified 12 relevant guidelines. Most studies and guidelines did not include any psychiatric involvement in the care of patients with pCFS. If psychiatry was mentioned, it was used interchangeably with psychological interventions or in the context of treating distinct psychiatric comorbidities and suicidal ideation.

Outlook

The role of psychiatry in diagnosis and treatment of pCFS is poorly defined. Future research is required to understand how psychiatrists can contribute to the care of patients with pCFS.


Corresponding author: David PR Wardle, Department of Psychiatry, Queen’s University, Kingston, ON, K7L2V7, Canada, E-mail:

Acknowledgments

Sarah Wickett, MLIS, a health sciences librarian at Queen’s University who assisted in developing the search strategy.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

References

1. Medicine Io. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: redefining an illness. Washington, DC: The National Academies Press; 2015:304 p.Search in Google Scholar

2. Rusu, C, Gee, ME, Lagace, C, Parlor, M. Chronic fatigue syndrome and fibromyalgia in Canada: prevalence and associations with six health status indicators. Health Promot Chronic Dis Prev Can 2015;35:3–11. https://doi.org/10.24095/hpcdp.35.1.02.Search in Google Scholar PubMed PubMed Central

3. Crawley, EM, Emond, AM, Sterne, JA. Unidentified chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a major cause of school absence: surveillance outcomes from school-based clinics. BMJ Open 2011;1:e000252. https://doi.org/10.1136/bmjopen-2011-000252.Search in Google Scholar PubMed PubMed Central

4. Brigden, A, Loades, M, Abbott, A, Bond-Kendall, J, Crawley, E. Practical management of chronic fatigue syndrome or myalgic encephalomyelitis in childhood. Arch Dis Child 2017;102:981–6. https://doi.org/10.1136/archdischild-2016-310622.Search in Google Scholar PubMed PubMed Central

5. (CDC) CFDCaP. Myalgic encephalomyelitis/chronic fatigue syndrome – me/CFS in children 2022. Available from: https://www.cdc.gov/me-cfs/me-cfs-children/index.html [Accessed 2 Jun 2022].Search in Google Scholar

6. Rangel, L, Garralda, ME, Levin, M, Roberts, H. The course of severe chronic fatigue syndrome in childhood. J R Soc Med 2000;93:129–34. https://doi.org/10.1177/014107680009300306.Search in Google Scholar PubMed PubMed Central

7. Jason, LA, King, CP, Richman, JA, Taylor, RR, Torres, SR, Song, SUS. Case definition of chronic fatigue syndrome. J Chronic Fatigue Syndrome 1999;5:3–33. https://doi.org/10.1300/j092v05n03_02.Search in Google Scholar

8. Carruthers, BM, van de Sande, MI, De Meirleir, KL, Klimas, NG, Broderick, G, Mitchell, T, et al.. Myalgic encephalomyelitis: international consensus criteria. J Intern Med 2011;270:327–38. https://doi.org/10.1111/j.1365-2796.2011.02428.x.Search in Google Scholar PubMed PubMed Central

9. National Institute for Health and Care Excellence: Guidelines. Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management. London: National Institute for Health and Care Excellence (NICE) Copyright © NICE 2021; 2021.Search in Google Scholar

10. Health RCoPaC. Evidence based guideline for the management of CFS/ME (Chronic Fatigue Syndrome/Myalgic Encephalopathy) in children and young people. London: Royal College of Paediatrics and Child Health; 2004.Search in Google Scholar

11. Garralda, ME, Chalder, T. Practitioner review: chronic fatigue syndrome in childhood. J Child Psychol Psychiatry Allied Discip 2005;46:1143–51. https://doi.org/10.1111/j.1469-7610.2005.01424.x.Search in Google Scholar PubMed

12. Diagnostic and statistical manual of mental disorders: DSM-5-TR, 5th ed., text revision. ed. Washington, DC: American Psychiatric Association Publishing; 2022.Search in Google Scholar

13. (WHO) WHO. Chronic fatigue syndrome 2023. Available from: https://www.who.int/standards/classifications/frequently-asked-questions/chronic-fatigue-syndrome.Search in Google Scholar

14. Browne, T, Chalder, T. Chronic fatigue syndrome. Psychiatry 2006;5:48–51. https://doi.org/10.1383/psyt.2006.5.2.48.Search in Google Scholar

15. Nijhof, SL, Priesterbach, LP, Uiterwaal, CS, Bleijenberg, G, Kimpen, JL, van de Putte, EM. Internet-based therapy for adolescents with chronic fatigue syndrome: long-term follow-up. Pediatrics 2013;131:e1788–95. https://doi.org/10.1542/peds.2012-2007.Search in Google Scholar PubMed

16. Knoop, H, Stulemeijer, M, de Jong, LW, Fiselier, TJ, Bleijenberg, G. Efficacy of cognitive behavioral therapy for adolescents with chronic fatigue syndrome: long-term follow-up of a randomized, controlled trial. Pediatrics 2008;121:e619–25. https://doi.org/10.1542/peds.2007-1488.Search in Google Scholar PubMed

17. Jordan, KM, Landis, DA, Downey, MC, Osterman, SL, Thurm, AE, Jason, LA. Chronic fatigue syndrome in children and adolescents: a review. J Adolesc Health 1998;22:4–18. https://doi.org/10.1016/s1054-139x(97)00212-7.Search in Google Scholar PubMed

18. Richards, J, Smith, F. Chronic fatigue syndrome in children and adolescents: general practitioners’ experience of the problem and their views about its treatment. Psychiatr Bull 1998;22:203–6. https://doi.org/10.1192/pb.22.4.203.Search in Google Scholar

19. Crawley, E, Sterne, JA. Association between school absence and physical function in paediatric chronic fatigue syndrome/myalgic encephalopathy. Arch Dis Child 2009;94:752–6. https://doi.org/10.1136/adc.2008.143537.Search in Google Scholar PubMed

20. Falk Hvidberg, M, Brinth, LS, Olesen, AV, Petersen, KD, Ehlers, L. The health-related quality of life for patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PLoS One 2015;10:e0132421. https://doi.org/10.1371/journal.pone.0132421.Search in Google Scholar PubMed PubMed Central

21. Clery, P, Royston, A, Driver, K, Bailey, J, Crawley, E, Loades, M. What treatments work for anxiety and depression in children and adolescents with chronic fatigue syndrome? An updated systematic review. BMJ Open 2022;12:e051358. https://doi.org/10.1136/bmjopen-2021-051358.Search in Google Scholar PubMed PubMed Central

22. Grant, MJ, Booth, A. A typology of reviews: an analysis of 14 review types and associated methodologies. Health Inf Libr J 2009;26:91–108. https://doi.org/10.1111/j.1471-1842.2009.00848.x.Search in Google Scholar PubMed

23. Sunde, KE, Hilliker, DR, Fischer, PR. Understanding and managing adolescents with conversion and functional disorders. Pediatr Rev 2020;41:630–41. https://doi.org/10.1542/pir.2019-0042.Search in Google Scholar PubMed

24. Werker, CL, Nijhof, SL, Van De Putte, EM. Clinical practice: chronic fatigue syndrome. Eur J Pediatr 2013;172:1293–8. https://doi.org/10.1007/s00431-013-2058-8.Search in Google Scholar PubMed

25. Afari, N, Buchwald, D. Chronic fatigue syndrome: a review. Am J Psychiatry 2003;160:221–36. https://doi.org/10.1176/appi.ajp.160.2.221.Search in Google Scholar PubMed

26. Garralda, ME. Psychiatric management of severe somatoform disorders in childhood and adolescence. Acta Neuropsychiatr 2002;14:85–9. https://doi.org/10.1034/j.1601-5215.2002.140207.x.Search in Google Scholar PubMed

27. Richards, J. Chronic fatigue syndrome in children and adolescents: a review article. Clin Child Psychol Psychiatr 2000;5:31–51. https://doi.org/10.1177/1359104500005001005.Search in Google Scholar

28. Garralda, ME. Practitioner review: assessment and management of somatisation in childhood and adolescence: a practical perspective. J Child Psychol Psychiatry Allied Discip 1999;40:1159–67. https://doi.org/10.1111/1469-7610.00533.Search in Google Scholar

29. Wessely, S, Chalder, T, Hirsch, S, Wallace, P, Wright, D. Psychological symptoms, somatic symptoms, and psychiatric disorder in chronic fatigue and chronic fatigue syndrome: a prospective study in the primary care setting. Am J Psychiatr 1996;153:1050–9. https://doi.org/10.1176/ajp.153.8.1050.Search in Google Scholar PubMed

30. Gordon, B, Lubitz, L. Promising outcomes of an adolescent chronic fatigue syndrome inpatient programme. J Paediatr Child Health 2009;45:286–90. https://doi.org/10.1111/j.1440-1754.2009.01493.x.Search in Google Scholar PubMed

31. Saidi, G, Haines, L. The management of children with chronic fatigue syndrome-like illness in primary care: a cross-sectional study. Br J Gen Pract 2006;56:43–7.Search in Google Scholar

32. Vereker, MI. Chronic fatigue syndrome: a joint paediatric-psychiatric approach. Arch Dis Child 1992;67:550–5. https://doi.org/10.1136/adc.67.4.550.Search in Google Scholar PubMed PubMed Central

33. Webb, CM, Collin, SM, Deave, T, Haig-Ferguson, A, Spatz, A, Crawley, E. What stops children with a chronic illness accessing health care: a mixed methods study in children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). BMC Health Serv Res 2011;11:308. https://doi.org/10.1186/1472-6963-11-308.Search in Google Scholar PubMed PubMed Central

34. Tricco, AC, Lillie, E, Zarin, W, O’Brien, KK, Colquhoun, H, Levac, D, et al.. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med 2018;169:467–73. https://doi.org/10.7326/m18-0850.Search in Google Scholar

35. Sandler, CX, Lloyd, AR. Chronic fatigue syndrome: progress and possibilities. Med J Aust 2020;212:428–33. https://doi.org/10.5694/mja2.50553.Search in Google Scholar PubMed

36. Mehta, N. Mind-body dualism: a critique from a health perspective. Mens Sana Monogr 2011;9:202–9. https://doi.org/10.4103/0973-1229.77436.Search in Google Scholar PubMed PubMed Central


Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/ijamh-2023-0030).


Received: 2023-03-10
Accepted: 2023-05-30
Published Online: 2023-06-20

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 6.6.2024 from https://www.degruyter.com/document/doi/10.1515/ijamh-2023-0030/html
Scroll to top button