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Metabolic syndrome in Iranian adolescents with polycystic ovary syndrome

  • Mohammad H. Dabbaghmanesh , Tahereh Naderi , Marzieh Akbarzadeh EMAIL logo and Hamidreza Tabatabaee

Abstract

Background

Metabolic syndrome (MS) in adolescents is a risk factor for type 2 diabetes and cardiovascular diseases.

Objective

The present study aimed to determine the prevalence of MS in 14–18-year-old girls.

Methods

This analytical case-control study was conducted on 3200 high school students with polycystic ovarian syndrome (PCOS). PCOS was confirmed by an endocrinologist after detection of clinical hyperandrogenism (acne, hirsutism and alopecia) and oligomenorrhea, rejection of hypothyroidism and hyperprolactinemia and performance of abdominal sonography. In the second stage, the prevalence of MS was compared between 70 girls with PCOS and 45 healthy girls using the ATPIII, Cooki and Ferranti scales. The study data were collected using a demographic questionnaire, body mass index (BMI) graph, the WC graph and standard blood pressure graph in adolescents. Then, the data were analyzed using the t-test and the χ2-test.

Results

Based on the Ferranti scale, the prevalence of MS was 10.4% and 0% in the case and control groups, respectively. The highest prevalence was related to hyperandrogenism and polycystic ovaries phenotype (11.6% vs. 0%, p = 0.05). Based on the Cooki and ATPIII scales, the prevalence of this disorder was 4.1% in the case group and 0.67% in the control group, with the highest rate being related to hyperandrogenism, oligomenorrhea and polycystic ovaries phenotype (7.5% vs. 0%, p = 0.28).

Conclusion

In comparison to the control group, the prevalence of MS in the patients with PCOS was 10-fold higher according to the Ferranti scale and nearly 3.5-fold higher based on the Cooki and ATPIII scales. Thus, long-term follow-up is suggested in these patients.

Acknowledgments

This article was extracted from the research proposal approved by Student Research Committee of Shiraz University of Medical Sciences (proposal No. 6020). The authors would like to thank the Student Research Committee of Shiraz University of Medical Sciences for financially supporting this research. The authors would also like to thank Shiraz University of Medical Sciences, Shiraz, Iran and also Center for Development of Clinical Research of Nemazee Hospital and Dr. Nasrin Shokrpour for editorial assistance.

  1. Authors’ Contribution: T. Naderi, M. Akbarzadeh and M.H. Dabbaghmanesh conceived of the study and participated in its design and coordination and helped to draft the manuscript. T. Naderi collected the data. M. Akbarzadeh and H.R. Tabatabaee performed the statistical analysis. T. Naderi and M. Akbarzadeh made critical revisions to the paper and translated it into English. All authors read and approved the final version of the paper.

  2. Financial disclosure: There is no financial disclosure.

  3. Funding/Support: This study was financially supported by Student Research Committee of Shiraz University of Medical Sciences Shiraz, Iran.

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Received: 2017-02-17
Accepted: 2017-05-10
Published Online: 2017-08-05

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