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Licensed Unlicensed Requires Authentication Published by De Gruyter March 2, 2023

Determinants of synergistic cell-cell interactions in bacteria

  • Benedikt Pauli ORCID logo , Shiksha Ajmera ORCID logo and Christian Kost ORCID logo EMAIL logo
From the journal Biological Chemistry

Abstract

Bacteria are ubiquitous and colonize virtually every conceivable habitat on earth. To achieve this, bacteria require different metabolites and biochemical capabilities. Rather than trying to produce all of the needed materials by themselves, bacteria have evolved a range of synergistic interactions, in which they exchange different commodities with other members of their local community. While it is widely acknowledged that synergistic interactions are key to the ecology of both individual bacteria and entire microbial communities, the factors determining their establishment remain poorly understood. Here we provide a comprehensive overview over our current knowledge on the determinants of positive cell-cell interactions among bacteria. Taking a holistic approach, we review the literature on the molecular mechanisms bacteria use to transfer commodities between bacterial cells and discuss to which extent these mechanisms favour or constrain the successful establishment of synergistic cell-cell interactions. In addition, we analyse how these different processes affect the specificity among interaction partners. By drawing together evidence from different disciplines that study the focal question on different levels of organisation, this work not only summarizes the state of the art in this exciting field of research, but also identifies new avenues for future research.


Corresponding author: Christian Kost, Department of Ecology, School of Biology/Chemistry, Osnabrück University, D-49076 Osnabrück, Germany; and Center of Cellular Nanoanalytics (CellNanOs), Osnabrück University, Barbarastrasse 11, D-49076 Osnabrück, Germany, E-mail:
Benedikt Pauli and Shiksha Ajmera contributed equally to this work.

Funding source: Volkswagen Foundation

Award Identifier / Grant number: Az: 9B831

Funding source: Deutsche Forschungsgemeinschaft

Award Identifier / Grant number: KO 3909/2-1

Award Identifier / Grant number: KO 3909/4-1

Award Identifier / Grant number: KO 3909/6-1

Award Identifier / Grant number: KO 3909/9-1

Award Identifier / Grant number: SFB 944, P19

Acknowledgements

The authors would like to thank all members of the Kostlab (past and present) as well as the SFB 944 for valuable discussion. This work was funded by the German Research Foundation (DFG: SFB 944, P19, KO 3909/2-1, KO 3909/4-1, KO 3909/6-1, KO 3909/9-1) and the Volkswagen Foundation (Az: 9B831).

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was financiallly supported by the German Research Foundation (Grant number: DFG: SFB 944, P19), Deutsche Forschungsgemeinschaft (Grant number: KO 3909/2-1, KO 3909/4-1, KO 3909/6-1, KO 3909/9-1), Volkswagen Foundation (Grant number: Az: 9B831).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/hsz-2022-0303).


Received: 2022-10-05
Accepted: 2023-02-08
Published Online: 2023-03-02
Published in Print: 2023-04-25

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