One-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones using a novel ionic liquid as an efficient and reusable catalyst: improved protocol conditions for the Biginelli-like scaffolds

Banothu Janardhan; Somarapu Vijaya Laxmi; Bavanthu Rajitha

doi:10.1515/hc-2011-0109

Open Access Published by De Gruyter March 17, 2012

One-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones using a novel ionic liquid as an efficient and reusable catalyst: improved protocol conditions for the Biginelli-like scaffolds

Banothu Janardhan , Somarapu Vijaya Laxmi and Bavanthu Rajitha

From the journal Heterocyclic Communications

https://doi.org/10.1515/hc-2011-0109

Abstract

A novel ionic liquid with multi-SO₃H groups has been found to be an efficient acid catalyst for the one-pot three-component synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones under solvent free conditions. Good yields, short reaction times, straight forward workup, reusability of the catalyst and green conditions are the most obvious advantages of this methodology.

Keywords: fused 3,4-dihydropyrimidin-2(1H)-ones; novel ionic liquid with multi-SO3H groups; one-pot synthesis; solvent free conditions; thiones

Corresponding author

Received: 2011-11-7

Accepted: 2012-1-24

Published Online: 2012-03-17

Published in Print: 2012-04-01

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

One-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones using a novel ionic liquid as an efficient and reusable catalyst: improved protocol conditions for the Biginelli-like scaffolds

Abstract

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