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Research ethics: Not applicable as this is an internal laboratory investigation.
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Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.
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Author contributions: Conceptualization: Lee CK, Koay ESK, Tan M, and Loh TP; Methodology: Lee CK, Huan PT, Chai CN, Ng LJ, Lee OF, and Loh TP; Validation: Lee CK and Loh TP; Formal analysis: Lee CK and Lee OF; Investigation: Lee CK, Huan PT, Chai CN, Ng LJ, Lee OF, and Loh TP; Resources: Lee CK, Koay ESK, Tan M, and Loh TP. Data curation: Lee CK; Writing – original draft preparation: Lee CK, Lee OF, Tan M, and Loh TP; Writing – review and editing: all authors; Visualization: Lee OF; Supervision: Lee CK; Project administration: Lee CK, Koay ESK, and Loh TP. The authors have accepted responsibility for the entire content of this manuscript and approved its submission. We affirm that the material is original research, has not been previously published and has not been submitted for publication elsewhere while under consideration.
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Competing interests: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: The raw data can be obtained on request from the corresponding author.
References
1. Lennard, L, Van Loon, JA, Weinshilboum, RM. Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther 1989;46:149–54. https://doi.org/10.1038/clpt.1989.119.Search in Google Scholar PubMed
2. Abaji, R, Krajinovic, M. Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response. Pharmgenomics Pers Med 2017;10:143–56. https://doi.org/10.2147/pgpm.s108123.Search in Google Scholar PubMed PubMed Central
3. Lee, CK, Loh, TP, Wong, ST, Lee, HK, Huan, PT, Chiu, LL, et al.. Detection of a novel single nucleotide polymorphism of the human thiopurine s-methyltransferase gene in a Chinese individual. Drug Metabol Pharmacokinet 2012;27:559–61. https://doi.org/10.2133/dmpk.dmpk-12-sc-008.Search in Google Scholar PubMed
4. Lee, CK, Lee, HK, Huan, PT, Chiu, LL, Loh, TP, Koay, ESC. A point mutation in the thiopurine S-methyltransferase gene that led to exon 5 deletion in the transcribed mRNA. Clin Chem Lab Med 2016;54:e301–3. https://doi.org/10.1515/cclm-2015-1170.Search in Google Scholar PubMed
5. Otterness, DM, Szumlanski, CL, Wood, TC, Weinshilboum, RM. Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity. J Clin Invest 1998;101:1036–44. https://doi.org/10.1172/jci1004.Search in Google Scholar PubMed PubMed Central
6. Lee, D, Szumlanski, C, Houtman, J, Honchel, R, Rojas, K, Overhauser, J, et al.. Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1. Drug Metab Dispos 1995;23:398–405.Search in Google Scholar
7. Kham, SKY, Soh, CK, Aw, DCW, Yeoh, AEJ. TPMT*26 (208F-->L), a novel mutation detected in a Chinese. Br J Clin Pharmacol 2009;68:120–3. https://doi.org/10.1111/j.1365-2125.2009.03405.x.Search in Google Scholar PubMed PubMed Central
8. Collie-Duguid, ES, Pritchard, SC, Powrie, RH, Sludden, J, Collier, DA, Li, T, et al.. The frequency and distribution of thiopurine methyltransferase alleles in caucasian and Asian populations. Pharmacogenetics 1999;9:37–42. https://doi.org/10.1097/00008571-199902000-00006.Search in Google Scholar PubMed
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