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Abiraterone acetate: a potential source of interference in testosterone assays

  • Benjamin P. Fairfax , Robert D. Morgan , Andrew Protheroe EMAIL logo , Brian Shine and Timothy James

Corresponding author: Professor Andrew Protheroe, PhD FRCP, Department of Oncology, Oxford Cancer Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Old Road, Headington, Oxford OX3 7LE, UK, Phone: +44(0) 1865 235275

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

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3. Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 2008;68:4447–54.10.1158/0008-5472.CAN-08-0249Search in Google Scholar PubMed PubMed Central

4. de Bono JS, Logothetis CJ, Molina A, Fizazi K, North S, Chu L, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 2011;364:1995–2005.10.1056/NEJMoa1014618Search in Google Scholar PubMed PubMed Central

5. Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza P, et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. N Engl J Med 2013;368: 138–48.10.1056/NEJMoa1209096Search in Google Scholar PubMed PubMed Central

6. Attard G, Reid AH, Auchus RJ, Hughes BA, Cassidy AM, Thompson E, et al. Clinical and biochemical consequences of cyp17a1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer. J Clin Endocrinol Metab 2012;97:507–16.10.1210/jc.2011-2189Search in Google Scholar PubMed

Received: 2017-7-17
Accepted: 2017-11-27
Published Online: 2018-1-5
Published in Print: 2018-5-24

©2018 Walter de Gruyter GmbH, Berlin/Boston

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