Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Published by De Gruyter 2019

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Edited by: Peggy L. Carver
With contributions by: Bernard Meunier , Anne Robert , Guido Crisponi , Valeria Nurchi , Joanna I. Lachowicz , Manfred Nairz , Guenter Weiss , Amy B. Pai , Roberta J. Ward , Robert R. Crichton , Keith M. Erikson , Michael Aschner , Jay Lopez , Divya Ramchandani , Linda T. Vahdat , Debbie C. Crans , Barry I. Posner , Aviva Levina , Peter A. Lay , Elizabeth A. Bajema , Kaleigh Roberts , Thomas J. Meade , Dinorah Gambino , Lucía Otero , Elzbieta Gumienna-Kontecka , Sigrídur G. Suman and Johanna M. Gretarsdottir

Volume 19 in the series Metal Ions in Life Sciences

https://doi.org/10.1515/9783110527872

Overview
Contents

About this book

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Creates a unique snapshot of current understanding of the role metal ions play in biology and medicine.
Connects biochemistry of metal ions to human theraupetics.
Written by internationally recognized experts.

Author / Editor information

Peggy L. Carver, College of Pharmacy, University of Michigan, Ann Arbor, USA.

Reviews

"In conclusion, this volume of MILS lives up in every way to the high standard set by previous volumes. I recommend it as strongly as possible not only to those individuals or institutions with a regular subscription to the series, but also to any researcher with an interest in the medical/medicinal/health (however one might distinguish amongst these areas) aspects of metal ions. Thus, both clinical and basic researchers would benefit greatly from volume 19 of MILS."
Joshua Telser in: Coordination Chemistry Reviews 392 (2019), 81-82

"Overall, this volume is a nice compilation of articles describing some of the emerging therapeutic uses of metals in medicine. Each chapter has an extensive literature survey which would be of benefit to the researchers in their areas. It would also serve as an excellent introduction to readers interested in metals in medicine and their possible therapeutic benefits."
Bibudhendra Sarkar in: Journal of Inorganic Biochemistry 199 (2019), DOI https://doi.org/10.1016/j.jinorgbio.2019.110794

Topics

Frontmatter Publicly Available Download PDF	i
About the Editors Publicly Available Download PDF	v
Historical Development and Perspectives of the Series Astrid Sigel, Helmut Sigel and Roland K. O. Sigel Publicly Available Download PDF	vii
Preface to Volume 19 Publicly Available Download PDF	ix
Contents Publicly Available Download PDF	xiii
Contributors to Volume 19 Publicly Available Download PDF	xix
Titles of Volumes 1–44 in the Metal Ions in Biological Systems Series Publicly Available Download PDF	xxiii
Contents of Volumes in the Metal Ions in Life Sciences Series Publicly Available Download PDF	xxv
1. METALS IN MEDICINE: THE THERAPEUTIC USE OF METAL IONS IN THE CLINIC Peggy L. Carver Requires Authentication Unlicensed Licensed Download PDF	1
2. SMALL MOLECULES: THE PAST OR THE FUTURE IN DRUG INNOVATION? Anne Robert, Françoise Benoit-Vical, Yan Liu and Bernard Meunier Requires Authentication Unlicensed Licensed Download PDF	17
3. IRON CHELATION FOR IRON OVERLOAD IN THALASSEMIA Guido Crisponi, Valeria M. Nurchi and Joanna I. Lachowicz Requires Authentication Unlicensed Licensed Download PDF	49
4. IRONING OUT THE BRAIN Roberta J. Ward and Robert R. Crichton Requires Authentication Unlicensed Licensed Download PDF	87
5. INFECTIONS ASSOCIATED WITH IRON ADMINISTRATION Manfred Nairz and Guenter Weiss Requires Authentication Unlicensed Licensed Download PDF	123
6. IRON OXIDE NANOPARTICLE FORMULATIONS FOR SUPPLEMENTATION Amy Barton Pai Requires Authentication Unlicensed Licensed Download PDF	157
7. BUILDING A TROJAN HORSE: SIDEROPHORE-DRUG CONJUGATES FOR THE TREATMENT OF INFECTIOUS DISEASES Elzbieta Gumienna-Kontecka and Peggy L. Carver Requires Authentication Unlicensed Licensed Download PDF	181
8. DEVELOPING VANADIUM AS AN ANTIDIABETIC OR ANTICANCER DRUG: A CLINICAL AND HISTORICAL PERSPECTIVE Debbie C. Crans, LaRee Henry, Gabriel Cardiff and Barry I. Posner Requires Authentication Unlicensed Licensed Download PDF	203
9. CHROMIUM SUPPLEMENTATION IN HUMAN HEALTH, METABOLIC SYNDROME, AND DIABETES Wolfgang Maret Requires Authentication Unlicensed Licensed Download PDF	231
10. MANGANESE: ITS ROLE IN DISEASE AND HEALTH Keith M. Erikson and Michael Aschner Requires Authentication Unlicensed Licensed Download PDF	253
11. COBALT-SCHIFF BASE COMPLEXES: PRECLINICAL RESEARCH AND POTENTIAL THERAPEUTIC USES Elizabeth A. Bajema, Kaleigh F. Roberts and Thomas J. Meade Requires Authentication Unlicensed Licensed Download PDF	267
12. COPPER DEPLETION AS A THERAPEUTIC STRATEGY IN CANCER Jay Lopez, Divya Ramchandani and Linda Vahdat Requires Authentication Unlicensed Licensed Download PDF	303
13. METAL COMPOUNDS IN THE DEVELOPMENT OF ANTIPARASITIC AGENTS: RATIONAL DESIGN FROM BASIC CHEMISTRY TO THE CLINIC Dinorah Gambino and Lucía Otero Requires Authentication Unlicensed Licensed Download PDF	331
14. CHEMICAL AND CLINICAL ASPECTS OF METAL-CONTAINING ANTIDOTES FOR POISONING BY CYANIDE Sigridur G. Suman and Johanna M. Gretarsdottir Requires Authentication Unlicensed Licensed Download PDF	359
SUBJECT INDEX Requires Authentication Unlicensed Licensed Download PDF	393

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Scientists in biochemistry, inorganic chemistry, medicine, pharmacy, toxicology, and molecular biology.
Pages
- Front matter: 43
- Main content: 412
Illustrations
- Coloured Illustrations: 150
- Tables: 100
Keywords: Bioanorganische Chemie; Koordinationschemie; Arzneimitteldesign; Anorganische Chemie

eBook

Published: January 14, 2019
ISBN: 9783110527872

Hardcover

Published: January 14, 2019
ISBN: 9783110526912