Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
ORIGINALS
Decrease of Intrathyroidal CD161+Vα24+Vβ11+ NKT Cells in Graves' disease
Mikio WATANABEYukiyo NAKAMURAFumio MATSUZUKAYuuki TAKAMURAAkira MIYAUCHIYoshinori IWATANI
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2008 Volume 55 Issue 1 Pages 199-203

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Abstract

To clarify changes in the intrathyroidal natural killer T (NKT) cell subset, which prevents autoimmunity in patients with Graves' disease (GD), we examined intrathyroidal and peripheral lymphocytes in 11 patients with GD and peripheral lymphocytes in nine healthy volunteers using three-color flow cytometry. The proportion of CD161 + T cell receptor Vα24 + Vβ11 + cells, which represent the NKT cell subset, was lower in the thyroid of patients with GD than in the peripheral blood of the same patients and in the peripheral blood of healthy subjects. These results indicate that the proportion of intrathyroidal NKT cells is decreased in patients with GD and that this decrease may contribute to incomplete regulation of autoreactive T cells in GD.

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© The Japan Endocrine Society
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