Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population

Shigeru KARASAWA; Makoto DAIMON; Satoshi SASAKI; Sayumi TORIYAMA; Toshihide OIZUMI; Shinji SUSA; Wataru KAMEDA; Kiriko WADA; Masaaki MURAMATSU; Akira FUKAO; Isao KUBOTA; Sumio KAWATA; Takamasa KAYAMA; Takeo KATO

doi:10.1507/endocrj.K09E-305

ORIGINALS

Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population

Shigeru KARASAWA, Makoto DAIMON, Satoshi SASAKI, Sayumi TORIYAMA, Toshihide OIZUMI, Shinji SUSA, Wataru KAMEDA, Kiriko WADA, Masaaki MURAMATSU, Akira FUKAO, Isao KUBOTA, Sumio KAWATA, Takamasa KAYAMA, Takeo KATO

Author information

Shigeru KARASAWA
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
Makoto DAIMON
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
Satoshi SASAKI
Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo, Tokyo, Japan
Sayumi TORIYAMA
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
HuBit Genomix Research Institute, Tokyo, Japan
Toshihide OIZUMI
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
Shinji SUSA
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
Wataru KAMEDA
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
Kiriko WADA
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
Masaaki MURAMATSU
HuBit Genomix Research Institute, Tokyo, Japan
Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Akira FUKAO
Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
Isao KUBOTA
Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
Sumio KAWATA
Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
Takamasa KAYAMA
Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan
Takeo KATO
Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata, Japan

Keywords: FTO gene polymorphism, Gene environmental interaction, Physical activity, Nutritional intake, Population-based study

JOURNAL FREE ACCESS

2010 Volume 57 Issue 4 Pages 293-301

DOI https://doi.org/10.1507/endocrj.K09E-305

View "Advance Publication" version (January 6, 2010).

Details

Abstract

The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 ± 10.2 years), a Japanese community-based study. The effects of lifestyle-related factors, including nutritional intake and physical activities, on the association were also examined. Body mass index (BMI) was significantly associated with the FTO gene polymorphism (p<0.001). A case-control association study of the FTO gene polymorphism with obesity using multiple logistic regression analysis showed a significant association of the genotype AA (odds ratio, 1.53 [95% confidential interval, 1.04-2.24]) after adjustment for age and gender. Analysis to examine the differences in lifestyle-related factors among the genotype groups showed a significant difference in the energy expenditure for moderate to high-intensity physical activity (PA) (≥ 3.0 METs) (p=0.012) with a significant decrease toward the genotype AA (p=0.027). The effect of energy expenditure for moderate to high-intensity PA on the association of the polymorphism with obesity was then examined using study groups stratified based on the energy expenditure for moderate to high-intensity PA (Low-PA and High-PA). The BMI was significantly higher in the genotype AA in the Low-PA group (p=0.016) but not in the High-PA group (p=0.103). Furthermore, the genotype AA was significantly associated with obesity (odds ratio, 2.39 [95% confidential interval, 1.19-4.80]) in the Low-PA group but not in the High- PA group (p=0.650). The FTO gene, rs9939609, was associated with obesity, and the association was evident in subjects with low-PA, suggesting a PA-dependent association.

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