Hypoglycemia Associated with the Production of Insulin-like Growth Factor II in a Pancreatic Islet Cell Tumor: A Case Report

Jin Ook CHUNG; Se In HONG; Dong Hyeok CHO; Jae Hyuk LEE; Dong Jin CHUNG; Min Young CHUNG

doi:10.1507/endocrj.K07E-153

NOTES

Hypoglycemia Associated with the Production of Insulin-like Growth Factor II in a Pancreatic Islet Cell Tumor: A Case Report

Jin Ook CHUNG, Se In HONG, Dong Hyeok CHO, Jae Hyuk LEE, Dong Jin CHUNG, Min Young CHUNG

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Keywords: Hypoglycemia, Insulin-like growth factor II, Insulinoma

JOURNAL FREE ACCESS

2008 Volume 55 Issue 3 Pages 607-612

DOI https://doi.org/10.1507/endocrj.K07E-153

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Abstract

An insulinoma is characterized by endogenous hyperinsulinemia and hypoglycemia. However, it has been reported that insulinomas with normal levels of plasma insulin and a normal insulin to glucose ratio occur in patients with hypoglycemia. Although overproduction of Insulin-like growth factor II (IGF-II) by non-islet cell tumors such as large mesenchymal tumors, can cause hypoglycemia, no cases of circulating plasma IGF-II from an islet cell tumor contributing to hypoglycemia have been reported. We report here a rare case of a pancreatic islet tumor in a patient with hypoglycemia that was associated with increased plasma IGF-II, which returned to normal after tumor resection.

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