Predictive Factor for Lymph Node Metastasis in Non-Metastatic Colorectal Adenocarcinomas
Ebru Karci1, Yuksel Urun2, Elif B Koksoy3, Gokhan Ucar4, Burak Bilgin5, Emre Yekeduz3, Cagatay Arslan61Department of Medical Oncology, Medipol Mega University Hospital, İstanbul, Türkiye, 2Depatment of Medical Oncology, Ankara University Faculty of Medicine, Ankara, Türkiye Depatment of Medical Oncology, Ankara University Faculty of Medicine, Ankara, Türkiye, 3Depatment of Medical Oncology, Ankara University Faculty of Medicine, Ankara, Türkiye, 4Department of Medical Oncology, Health of Science Ankara City Hospital, Ankara, Türkiye, 5Clinic of Medical Oncology, Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Türkiye, 6Department of Medical Oncology, Medical Park Hospital, Izmir, Türkiye
Objectives: To evaluate the predictive factors of lymph node involvement in non-metastatic colorectal adenocarcinomas (nmCRC). Methods: A total of 453 patients diagnosed with nmCRC were analyzed regarding T stage, lymphovascular invasion status, tumor grade and proposed risk score (RS), determined by the combination of these three factors for lymph node metastasis. Results: The median age was 62 (25-90 years), M/F ratio was 1.4:1 and majority of the patients had tumors localized on the left colon (70.6%). The number of excised lymph nodes was ?12 in 77% of the cases. The postoperative pathological assessments revealed that 57.2% of patie,nts had N0 disease, 29.1% had N1 disease, and 13.7% had N2 disease. The T stages (p=0.007), grade (p<0.001), lymphovascular invasion (p=0.002), RS (p<0.001), and number of excised lymph nodes (p=0.029) were significantly different between N0, N1, and N2 patients. Higher RS was associated with lymph node metastasis (p<0.001). Conclusion: The risk score may predict lymph node metastasis in patients with nmCRC and if validated may be helpful in the decision-making of adjuvant chemotherapy, especially in the elderly and patients with inadequate lymph node dissection.
Cite This Article
Karci E, Urun Y, Koksoy E, Ucar G, Bilgin B, Yekeduz E, Arslan C. Predictive Factor for Lymph Node Metastasis in Non-Metastatic Colorectal Adenocarcinomas. EJMI. 2022; 6(3): 279-283
Corresponding Author: Ebru Karci