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Opportunities for Combination Trials

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References

  1. Gauthier S, Alam J, Fillit H, et al. Combination Therapy for Alzheimer’s Disease: Perspectives of the EU/US CTAD Task Force. J Prev Alzheimer’s Dis in press

  2. Kishi T, Matsunaga S, Oya K, et al. Memantine for Alzheimer’s Disease: An Updated Systematic Review and Meta-analysis. J Alzheimers Dis. 2017;60(2):401–425. doi: https://doi.org/10.3233/JAD-170424. Review.

    Article  CAS  PubMed  Google Scholar 

  3. Howard R, McShane R, Lindesay J, et al. Donepezil and memantine for moderate-to-severe Alzheimer’s disease. N Engl J Med. 2012 Mar 8;366(10):893–903. doi: https://doi.org/10.1056/NEJMoa1106668.

    Article  CAS  PubMed  Google Scholar 

  4. Wilkinson D, Windfeld K, Colding-Jørgensen E. Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer’s disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2014 Nov;13(11):1092–1099. doi: https://doi.org/10.1016/S1474-4422(14)70198-X. Epub 2014 Oct 5.

    Article  CAS  PubMed  Google Scholar 

  5. Atri A, Frölich L, Ballard C, et al. Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials. JAMA. 2018 Jan 9;319(2):130–142. doi: https://doi.org/10.1001/jama.2017.20373.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ballard C, Banister C, Khan Z, et al. Evaluation of the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer’s disease psychosis: a phase 2, randomised, placebo-controlled, double-blind study. Lancet Neurol. 2018 Mar;17(3):213–222. doi: https://doi.org/10.1016/S1474-4422(18)30039-5. Erratum in: Lancet Neurol. 2018 Feb 26;:.

    Article  CAS  PubMed  Google Scholar 

  7. Spector A, Thorgrimsen L, Woods B, et al. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. Br J Psychiatry. 2003 Sep;183:248–54.

    Article  PubMed  Google Scholar 

  8. Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Jun 6;385(9984):2255–63. doi: https://doi.org/10.1016/S0140-6736(15)60461-5. Epub 2015 Mar 12.

    Article  PubMed  Google Scholar 

  9. Corbett A, Owen A, Hampshire A, et al. The Effect of an Online Cognitive Training Package in Healthy Older Adults: An Online Randomized Controlled Trial. J Am Med Dir Assoc. 2015 Nov 1;16(11):990–7. doi: https://doi.org/10.1016/j.jamda.2015.06.014.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. University of Exeter Medical School, St Luke’s Campus, University of Exeter, Magdelen Road, Exeter, UK

    Clive Ballard

  2. The University of Exeter, Exeter, UK

    A. Corbett

Authors
  1. Clive Ballard
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  2. A. Corbett
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Correspondence to Clive Ballard.

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Ballard, C., Corbett, A. Opportunities for Combination Trials. J Prev Alzheimers Dis 6, 177–178 (2019). https://doi.org/10.14283/jpad.2019.17

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  • DOI: https://doi.org/10.14283/jpad.2019.17

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