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Vol. 34 No. 4 (2022): Vol 34 Issue 4, 2022

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In vitro Cytotoxic Activity against MCF-7 Breast Cancer Cells Line: Pregabalin and Chiral Amino Acid-based Peptides

https://doi.org/10.14233/ajchem.2022.23566
V.B. Pansuriya
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009, India
P.V. Dholaria
BRCC Laboratory, Department of Chemistry, School of Science, R K University, Rajkot-360020, India
S.L. Rathod
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009, India
U.B. Prajapati
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009, India
B.M. Vavaiya
Department of Chemistry, M.G. Science College, Ahmedabad-380009, India
V.H. Marvaniya
Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandinagar-382421, India
F.U. Vaidya
Department of Cell Biology, School of Biological Sciences and Biotechnology, Indian Institute of Advanced Research, Gandhinagar-382426, India
C. Pathak
Department of Cell Biology, School of Biological Sciences and Biotechnology, Indian Institute of Advanced Research, Gandhinagar-382426, India
H.M. Parekh
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad-380009, India

Corresponding Author(s) : H.M. Parekh

hiteshparekh@gujaratuniversity.ac.in

Asian Journal of Chemistry, Vol. 34 No. 4 (2022): Vol 34 Issue 4, 2022

Abstract

Because of the medicinal application of peptides in the current drug discovery process, we report the synthesis and in vitro anticancer activity of various pregabalin containing peptides using chiral amino acids. The structures of newly synthesized compounds were assigned based on IR, 1H NMR, 13C NMR and mass spectral analysis. Synthesized peptides were screened for their anticancer activity on human breast cancer MCF-7 cells line by MMT assays method. Evaluation of anticancer activity shown that compound 13a (16.65% cell proliferation) was found to be most active against selected MCF-7 cell line.

Keywords

Peptide synthesis Pregabalin Cytotoxicity Breast cancer MCF-7 cell line
Pansuriya, V., Dholaria, P., Rathod, S., Prajapati, U., Vavaiya, B., Marvaniya, V., … Parekh, H. (2022). In vitro Cytotoxic Activity against MCF-7 Breast Cancer Cells Line: Pregabalin and Chiral Amino Acid-based Peptides. Asian Journal of Chemistry, 34(4), 871–878. https://doi.org/10.14233/ajchem.2022.23566
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References
  1. K. Kapadiya and R. Khunt, Lett. Drug Des. Discov., 16, 21 (2018); https://doi.org/10.2174/1570180815666180419151742
  2. S. Wanandi, A. Limanto, E. Yunita, R. Syahrani, M. Louisa, A.E. Wibowo and S. Arumsari, PLoS One, 16, e0247694 (2021); https://doi.org/10.1371/journal.pone.0247694
  3. D. Chowrasia, C. Karthikeyan, L. Choure, Sahabjada, M. Gupta, M. Arshad and P. Trivedi, Arab. J. Chem., 10, 2424 (2017); https://doi.org/10.1016/j.arabjc.2013.08.026
  4. M. Falzon and P. Du, Endocrinology, 141, 1882 (2000); https://doi.org/10.1210/endo.141.5.7470
  5. K. Miller, L. Nogueira, A. Mariotto, J. Rowland, K. Yabroff, C. Alfano, A. Jemal, J. Kramer and R. Siegel, Cancer J. Clin., 69, 363 (2019); https://doi.org/10.3322/caac.21565
  6. S. Marsh and H.L. McLeod, Expert Opin. Pharmacother., 8, 119 (2007); https://doi.org/10.1517/14656566.8.2.119
  7. N. Razak, N. Abu, W. Ho, N.R. Zamberi, S.W. Tan, N.B. Alitheen, K. Long and S.K. Yeap, Sci. Rep., 9, 1514 (2019); https://doi.org/10.1038/s41598-018-37796-w
  8. S. Atreya, Indian J. Palliat. Care, 22, 101 (2016); https://doi.org/10.4103/0973-1075.173941
  9. S. Wolf, D. Barton, L. Kottschade, A. Grothey and C. Loprinzi, J. Eur, Cancer, 44, 1507 (2008); https://doi.org/10.1016/j.ejca.2008.04.018
  10. K. Sjolund, Y. Yang, K. Lee and M. Resnick, Pain Ther., 2, 37 (2013); https://doi.org/10.1007/s40122-013-0009-8
  11. S.Y. Yoon and J. Oh, Korean J. Intern. Med., 33, 1058 (2018); https://doi.org/10.3904/kjim.2018.162
  12. A. Cicero, F. Fogacci and A. Colletti, Br. J. Pharmacol., 174, 1378 (2017); https://doi.org/10.1111/bph.13608
  13. Y. Mine, H. Munir, Y. Nakanishi and D. Sugiyama, Anticancer Res., 36, 3565 (2016).
  14. L. Yang, H. Liu, M. Long, X. Wang, F. Lin, Z. Gao and H. Zhang, OncoTargets Ther., 11, 2409 (2018); https://doi.org/10.2147/OTT.S154337
  15. L. Depau, J. Brunetti, C. Falciani, S. Scali, G. Riolo, E. Mandarini, A. Pini and L. Bracci, Oncotarget, 8, 76141 (2017); https://doi.org/10.18632/oncotarget.19056
  16. M. Xie, D. Liu and Y. Yang, Open Biol., 10, 200004 (2020); https://doi.org/10.1098/rsob.200004
  17. Y. Liscano, J. Onate-Garzon and J. Delgado, Molecules, 25, 4245 (2020); https://doi.org/10.3390/molecules25184245
  18. L. Wang, C. Dong, X. Li, W. Han and X. Su, Oncol. Rep., 38, 637 (2017); https://doi.org/10.3892/or.2017.5778
  19. F.U. Vaidya, R. Sharma, S. Shaikh, D. Ray, V.K. Aswal and C. Pathak, Cancer Reports, 2, e1133 (2019); https://doi.org/10.1002/cnr2.1133
  20. S. Bondock, S. Alqahtani and A. Fouda, J. Heterocycl. Chem., 58, 56 (2021); https://doi.org/10.1002/jhet.4148
  21. M. Wieduwilt and M. Moasser, Cell. Mol. Life Sci., 65, 1566 (2008); https://doi.org/10.1007/s00018-008-7440-8
  22. M. Ghorab, M. Alsaid, M. El-Gaby, M. Elaasser and Y. Nissan, Chem. Cent. J., 11, 32 (2017); https://doi.org/10.1186/s13065-017-0258-4
  23. C. Pang, C. Sun, J. Wang, D. Xiao, L. Ding and H. Bu, Sci. China Chem., 56, 702 (2013); https://doi.org/10.1007/s11426-013-4840-x
  24. C. Martinez-Perez, C. Ward, A. Turnbull, P. Mullen, G. Cook, J. Meehan, E.J. Jarman, P.I.T. Thomson, C.J. Campbell, D. McPhail, D.J. Harrison and S.P. Langdon, Br. J. Cancer, 114, 905 (2016); https://doi.org/10.1038/bjc.2016.6
  25. R.R.J. Arroo, V. Androutsopoulos, K. Beresford, K. Ruparelia, S. Surichan, N. Wilsher and G.A. Potter, Phytochem. Rev., 8, 375 (2009); https://doi.org/10.1007/s11101-009-9128-6
  26. M. Egorin, Cancer Chemother. Pharmacol., 42(S1), S22 (1998); https://doi.org/10.1007/s002800051076
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