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Immune regulation by the TIM gene family

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Abstract

Recent studies have demonstrated that proteins of the T cell immunologobulin and mucin domain (TIM) family are important regulators of immune function. Here we discuss the functional effects of TIM proteins on immune responses, how the effects of TIM proteins may be modulated by interactions with ligands and the limited information available on intracellular signals downstream of TIM proteins.

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Author notes

  1. Lawrence P. Kane

    Present address: University of Pittsburgh, BSTE-1056, 200 Lothrop St., 15261, Pittsburgh, PA

Authors and Affiliations

  1. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Anjali J. de Souza & Lawrence P. Kane

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  1. Anjali J. de Souza
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  2. Lawrence P. Kane
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de Souza, A.J., Kane, L.P. Immune regulation by the TIM gene family. Immunol Res 36, 147–155 (2006). https://doi.org/10.1385/IR:36:1:147

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