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Lupus autoantigens: Their origins, forms, and presentation

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Abstract

The immune system has developed a number of mechanisms by which to distin guish self from foreign proteins. These mechanisms are found throughout the ontogeny of B and T cell development and include the deletion of autoreactive cells in central lymphoid organs and the induction of self-tolerance in the periphery. However, any failure of these mechanisms for self-tolerance may result in autoimmune disease. Efforts in our laboratory have been directed at under-standing how autoimmunity is initiated and maintained in both the B and T cell compartment, with particular interest in the autoimmunity of systemic lupus erythematosus (SLE). This review will focuson our studies on the forms of self-antigens that may be involved in the original “antigenic sin” of SLE and in the role of B lymphocytes as autoantigen presenting cells. We will also discuss whether costimulation is a formal requirement for the induction and maintenance of autoimmunity. Finally, we have provided a model for how all of these individual elements may contribute to the autoimmune processes leading to pathology.

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  1. Mark J. Mamula Ph.D.

    Present address: Yale University School of Medicine, 16520-8031, New Haven, CT

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  1. Yale University School of Medicine, 16520-8031, New Haven, CT

    Hester A. Doyle, Jun Yan & Bailin Liang

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Doyle, H.A., Yan, J., Liang, B. et al. Lupus autoantigens: Their origins, forms, and presentation. Immunol Res 24, 131–147 (2001). https://doi.org/10.1385/IR:24:2:131

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