Skip to main content
Log in

Granulomatous hypophysitis with psammoma bodies: A diagnostic dilemma

  • Case Report
  • Published:
Endocrine Pathology Aims and scope Submit manuscript

Abstract

We report a case of granulomatous hypophysitis with an unusual pathologic finding of psammoma bodies. This finding has not previously been described in the literature. The diagnostic implications of this finding are complex, and the pathogenesis of psammoma body formation in this idiopathic disorder remains unknown.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Sato N, Szeu G, Kim JH. Cystic pituitary mass in neurosarcoidosis. Am J Neuroradiol 18:1182–1185, 1997.

    PubMed  CAS  Google Scholar 

  2. Lohr KM, Ryan LM, Toohill RJ, Anderson T. Anterior pituitary involvement in Wegener’s granulomatosis. J Rheumatol 15:855–861, 1988.

    PubMed  CAS  Google Scholar 

  3. De Bruin WI, van’t Verlaat JW, Graamans K, et al. Sellar granulomatous mass in a pregnant woman with active Crohn’s disease. Neth J Med 39:136–141, 1991.

    PubMed  Google Scholar 

  4. Cheung CC, Ezzat S, Smyth HS, et al. The spectrum and significance of primary hypophysitis. J Clin Endocrinol Metab 86:1048–1053, 2001.

    Article  PubMed  CAS  Google Scholar 

  5. Sautner D, Saeger W, Ludecke DK, et al. Hypophysitis in surgical and autoptical specimens. Acta Neuropathol (Berl) 90:637–644, 1995.

    CAS  Google Scholar 

  6. Tashiro T, Sano T, Xu B, et al. Spectrum of different types of hypophysitis: a clinicopathologic study of hypophysitis in 31 cases. Endocr Pathol 13:183–195, 2002.

    Article  PubMed  Google Scholar 

  7. Kawahara K, Niguma T, Yoshino T, et al. Gastric carcinoma with psammomatous calcification after Billroth II reconstruction: case report and literature review. Pathol Int 51:718–722, 2001.

    Article  PubMed  CAS  Google Scholar 

  8. Niwa Y, Goto H, Hayakawa T, et al. Early gastric cancer with psammomatous calcification. Hepatogastroenterology 45:1527–1530, 1998.

    PubMed  CAS  Google Scholar 

  9. Nakayama H, Okumichi T, Nakashima S, et al. Papillary adenocarcinoma of the sigmoid colon associated with psammoma bodies and hyaline globules: report of a case. Jpn J Clin Oncol 27:193–196, 1997.

    Article  PubMed  CAS  Google Scholar 

  10. Pai SA, Krishnamurthy S, Soman CS, et al. Psammomatous carcinoid tumor of the duodenum. Indian J Gastroenterol 13:26–27, 1994.

    PubMed  CAS  Google Scholar 

  11. Schultz SM, Curry TS 3rd, Voet R, et al. Psammomatous-like calcification in a Brenner tumour of the ovary. Br J Radiol 59:412–414, 1986.

    Article  PubMed  CAS  Google Scholar 

  12. Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM. The pathobiologic spectrum of schwannomas. Histol Histopathol 18:925–934, 2003.

    PubMed  CAS  Google Scholar 

  13. Lee YS, Sen BK. Dystrophic and psammomatous calcifications in a desmoid tumor. A light microscopic and ultrastructural study. Cancer 55:84–90, 1985.

    Article  PubMed  CAS  Google Scholar 

  14. Hunt JL, Barnes EL. Non-tumor-associated psammoma bodies in the thyroid. Am J Clin Pathol 119:90–94, 2003.

    Article  PubMed  Google Scholar 

  15. Muntz HG, Goff BA, McGonigle K, et al. The significance of psammoma bodies in screening cervical cytologic smear. Am J Obstet Gynecol 188:1609–1612, 2003.

    Article  PubMed  Google Scholar 

  16. Parkash V, Chacho MS. Psammoma bodies in cervicovaginal smears: incidence and significance. Diagn Cytopathol 26:81–86, 2002.

    Article  PubMed  Google Scholar 

  17. Nicklin JL, Perrin L, Obermair A, et al. The significance of psammoma bodies on cervical cytology smears. Gynecol Oncol 83:6–9, 2001.

    Article  PubMed  CAS  Google Scholar 

  18. Zreik TG, Rutherford TJ. Psammoma bodies in cervicovaginal smears. Obstet Gynecol 97:693–695, 2001.

    Article  PubMed  CAS  Google Scholar 

  19. Bell CD, Kovacs K, Horvath E, et al. Papillary carcinoma of thyroid metastatic to the pituitary gland. Arch Pathol Lab Med 125:935–938, 2001.

    PubMed  CAS  Google Scholar 

  20. Terada T, Stefaneanu L, Kovacs K, et al. Vanishing psammoma bodies in the anterior pituitary of the human newborn: An immunohistochemical and histometric study. Endocr Pathol 7:151–157, 1996.

    PubMed  Google Scholar 

  21. Fausett MB, Zahn CM, Kendall BS, et al. The significance of psammoma bodies that are found incidentally during endometrial biopsy. Am J Obstet Gynecol 186:180–183, 2002.

    Article  PubMed  Google Scholar 

  22. Boon ME, Kirk RS, De Graaff Guilloud JC, et al. Psammoma bodies and some opportunistic infections detected in cervical smears of women fitted with an IUD. Contracept Deliv Syst 2(3):231–236, 1981.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. L. Asa MD, PhD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jastania, R., Nageeti, T., Kovacs, K. et al. Granulomatous hypophysitis with psammoma bodies: A diagnostic dilemma. Endocr Pathol 15, 359–363 (2004). https://doi.org/10.1385/EP:15:4:359

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1385/EP:15:4:359

Key Words

Navigation