Abstract
The present study in female rats determined the effects of experimental hyperthyroidsm on hemorheological parameters and fibrinogen concentration. To induce experimental hyperthyroidism l-thyroxine (0.4 mg/100 g fodder) was added to the fodder of the experimental group rats for 20 d. After experimental duration, T3, T4, and TSH levels, plasma and blood viscosity, hematocrit, erythrocyte rigidity index, and plasma fibrinogen concentration values of both the control and the experimental group animals were determined and evaluated. In the experimental group, T3 and T4 levels were higher and TSH levels lower than that of the control rats (respectively, p<0.01, p<0.001, p<0.001). Plasma viscosity and fibrinogen concentration of hyperthyroid group were found significantly higher than controls (p<0.01). However there was no significant difference found in blood viscosity, hematocrit, and erythrocyte rigidity index between control and experimental groups. Thus, hyperthyroidism induced increased fibrinogen concentration can alter the rheological structure of blood by inducing increase in plasma viscosity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Braverman, L. E. and Utiger, R. D. (eds.). (1996). Werner and Ingbar's the thyroid a fundamental and clinical text. 7th ed. Lippincott-Raven: Philadelphia, PA.
Yen, P. M. (2001). Phy. Rev. 81(3), 1097–1142.
Yigit, G. and Yigit, R. (2000). In: Tiroid Fizyolojisi. G. Ünal (ed.). I.U. CTF Yayinlari, Istanbul.
Biondi, B., Palmieri, E.A., Lombardi, G., and Fazio, S. (2002). Ann. Intern. Med. 137(11), 904–914.
Epstein, F. H. (2001). N. Engl. J. Med. 344, 501–509.
Hymes, K., Bloom, M., Kakner, H., and Karpatkin, S. (1981). Ann. Intern. Med. 94, 27–30.
Edson, J. R., Fecher, D. R., and Doe, R. P. (1975). Ann. Intern. Med. 82, 342–346.
Erem, C., Ersoz, H. O., Karti, S. S., et al. (2002). J. Endocrinol. Invest. 25(4), 345–350.
Li, Y., Chen, H., Tan, J., Wang, X., Liang, H., and Sun, X. (1998). Eur. J. Clin. Invest. 28(12), 1050–1054.
Kossler, A., Hagmuller, K., and Winkler, R. (1987). Biorheology 24, 769–774.
Herbert, V. (1986) In: Werner's the thyroid. Ingbar, S. H. and Braverman, L. E. (eds.). Lippincott: Philadelphia, PA.
Toktamis, N., Seven, A., Hacibekiroglu, M., et al. (1993). Biochem. Soc. Trans. 21(Pt3)(3), 223S.
Ruggiero, F. M., Landriscina, C., Gnoni, G. V., and Quagliariello, E. (1984). Horm. Metab. Res. 16, 37–40.
Marongiu, F., Conti, M., Mameli, G., et al. (1988). J. Endocrinol. Invest. 11, 723–725.
Burggraff, J., Lalezari, S., Emeis, J. J., et al. (2001). Thyroid 11(2), 153–160.
Lowe, G. D. (1999). Bailliere's Best Pract. Res. Clin. Haematol. 12(3), 435–449.
Matrai, A., Whittington, R. B., and Ernst, E. (1987). Clin. Hemorheol. 7, 261–265.
Kameneva, M. V., Garrett, K. O., Watach, M. J., and Borovetz, H. S. (1998). Clin. Hemorheol. Microcirc. 18, 67–74.
Toplan, S., Dariyerli, N., Özdemir, S., Akyolcu, M. C., Hatemi, H., and Yigit, G. (2005). Endocrine 28 (2), 153–156.
Bauer J. D. (1970). In: Gradwohl's clinical laboratory methods and diagnosis. Frankel, S., Reitman, S., and Sonnenwirt, A. C. (eds.). The C.V. Mosby Company: Saint Louis MO.
Ratnoff, O. D. and Menzie, C. (1951). J. Clin. Med. 37, 316–320.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Özdemir, S., Yücel, R., Dariyerli, N. et al. The effects of experimental hyperthyroidism on hemorheology and plasma fibrinogen concentration. Endocr 30, 203–205 (2006). https://doi.org/10.1385/ENDO:30:2:203
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/ENDO:30:2:203