Abstract
It is well known that rare earth elements (REEs) have come into extensive use in a number of fields. As a result, REEs are becoming closely related to human's daily life. However, until now, the distributions of REEs in the brain are not yet very clear. In this study, Sprague-Dawley male rats were intraperitoneally injected with 0.25 mL of 153SmCl3 solution (containing 10 μg Sm). The brain were perfused with saline to minimize the blood influence. The radioactivities of 153Sm in the five brain regions (hypothalamus, cerebellum, hippocampus, corpus striatum, and cerebral cortex) were counted. The results suggested that Sm did enter into the brain. Although only about 0.0003% of the given dose was accumulated in the brain, Sm seemed to be remain in the brain for a long time. The highest amounts and lowest concentrations of 153Sm were found in the cerebral cortex, and the highest concentrations of 153Sm were found in the hypothalamus.
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Xiao, H., Zhang, Z., Li, F. et al. Accumulation and distribution of samarium-153 in rat brain after intraperitoneal injection. Biol Trace Elem Res 104, 33–40 (2005). https://doi.org/10.1385/BTER:104:1:033
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DOI: https://doi.org/10.1385/BTER:104:1:033