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Primary non-Hodgkin’s lymphoma of the bone

A single institution experience

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Abstract

Primary non-Hodgkin’s lymphoma of the bone is an unusual entity. Twenty-five patients with diffuse large cell lymphoma of the bone were registered at the Tata Memorial Hospital (TMH) from August, 1991, to May, 2002. Pain at the local site and soft tissue swelling were the commonest symptoms. Involvement of the bones in the lower half of the body was more frequent than the bones in the upper half. Osteolytic lesions and an associated soft tissue mass were the common radiological findings. Nineteen patients received CHOP chemotherapy and five received COP chemotherapy. Twenty-three patients received involved field radiotherapy. The overall response to therapy was 96%. On follow-up, two patients had a nodal relapse. One patient died of progressive disease, and one patient died of cryptococcal meningitis. There were no deaths due to treatment-related toxicity. The mean progression free survival was 9.39 yr and the overall survival was 11.66 yr. The median overall survival has not been reached. At last follow-up, 21 patients were being following up at TMH and are free of disease.

Conclusion: Primary bone lymphoma is a malignancy that is highly curable with a combination of chemotherapy and radiotherapy.

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Author notes

  1. P. Parikh

    Present address: Tata Memorial Hospital Parel, Room No. 22, CRI building, 400012, Mumbai, INDIA

Authors and Affiliations

  1. Department of Medical Oncology In- Charge, Lymphoma Registry, Tata Memorial Hospital, Parel, Mumbai, India

    C. Deshmukh, A. Bakshi, P. Parikh, R. Nair, V. Pai, S. Gupta, A. Shaikh & T. Saikia

  2. Department of Radiation Oncology, In- Charge, Lymphoma Registry, Tata Memorial Hospital, Parel, Mumbai, India

    M. Muckaden

  3. Department of Pathology, In- Charge, Lymphoma Registry, Tata Memorial Hospital, Parel, Mumbai, India

    K. Naresh

Authors
  1. C. Deshmukh
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  2. A. Bakshi
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  3. P. Parikh
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  4. R. Nair
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  5. V. Pai
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  6. S. Gupta
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  7. A. Shaikh
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  8. M. Muckaden
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  9. K. Naresh
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  10. T. Saikia
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Deshmukh, C., Bakshi, A., Parikh, P. et al. Primary non-Hodgkin’s lymphoma of the bone. Med Oncol 21, 263–267 (2004). https://doi.org/10.1385/MO:21:3:263

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  • DOI: https://doi.org/10.1385/MO:21:3:263

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