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Detection of anti-tumor immunity induced by laser immunotherapy

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Abstract

Metastatic mammary tumors in rats were treated by laser immunotherapy. Tumors injected by a laser-absorbing dye and an immunoadjuvant were irradiated non-invasively by a near-infrared laser. The successfully cured rats developed a long-term resistance to repeated tumor challenges. Using the sera from cured rats as the source of primary antibodies, immune responses induced by laser immunotherapy were observed in both cellular and molecular levels using histochemical assays and Western blot analysis.

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Authors and Affiliations

  1. Biomedical Engineering Program, Department of Physics and Engineering, University of Central Oklahoma, 100 N. University Drive, 73034, Edmond, OK

    Wei R. Chen

  2. Department of Physics and Astronomy, University of Oklahoma, 73109, Norman, OK

    Wei R. Chen

  3. Wound Healing of Oklahoma, Inc., 3945 N. Walnut St., 73105, Oklahoma City, OK

    Raoul Carubelli & Robert E. Nordquist

  4. Center for Bioengineering and School of Electrical and Computer Engineering, University of Oklahoma, 73109, Norman, OK

    Hong Liu

Authors
  1. Wei R. Chen
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  2. Raoul Carubelli
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  3. Hong Liu
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  4. Robert E. Nordquist
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Chen, W.R., Carubelli, R., Liu, H. et al. Detection of anti-tumor immunity induced by laser immunotherapy. Mol Biotechnol 25, 45–51 (2003). https://doi.org/10.1385/MB:25:1:45

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  • DOI: https://doi.org/10.1385/MB:25:1:45

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