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Current Status of Clinical Islet Cell Transplantation

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Transplantation Immunology

Part of the book series: Methods In Molecular Biology™ ((MIMB,volume 333))

Abstract

Clinical outcomes of pancreas transplantation were superior to that of islet transplantation until the introduction of the Edmonton protocol. Significant advances in islet isolation and purification technology, novel immunosuppression and tolerance strategies, and effective antiviral prophylaxis have renewed interest in clinical islet transplantation for the treatment of diabetes mellitus. The introduction of a steroid-free antirejection protocol and islets prepared from two donors led to high rates of insulin independence. The Edmonton protocol has been successfully replicated by other centers in an international multicenter trial. A number of key refinements in pancreas transportation, islet preparation, and newer immunological conditioning and induction therapies have led to continued advancement through extensive collaboration between key centers. This chapter provides an overview of the history of islet transplantation followed by a discussion of the state of the art of clinical islet transplantation. The challenges facing the clinicianscientist in the 21st century are also presented in this review.

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Authors and Affiliations

  1. Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

    Jonathan R. T. Lakey, Mohammadreza Mirbolooki & A. M. James Shapiro

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  1. Jonathan R. T. Lakey
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  2. Mohammadreza Mirbolooki
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  3. A. M. James Shapiro
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Editors and Affiliations

  1. National Heart and Lung Institute, London, UK

    Philip Hornick

  2. National Heart and Lung Institute, Harefield, UK

    Marlene Rose

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Lakey, J.R.T., Mirbolooki, M., Shapiro, A.M.J. (2006). Current Status of Clinical Islet Cell Transplantation. In: Hornick, P., Rose, M. (eds) Transplantation Immunology. Methods In Molecular Biology™, vol 333. Humana Press. https://doi.org/10.1385/1-59745-049-9:47

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  • DOI: https://doi.org/10.1385/1-59745-049-9:47

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-544-6

  • Online ISBN: 978-1-59745-049-2

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