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Bone Metastasis pp 59–74Cite as

Role of TGF-β and IGF in Tumor Progression and Bone Metastases

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Metastatic disease contributes to a large proportion of cancer-related deaths, and bone is among the most common sites for metastases for tumors originating in the breast and prostate. The propensity for these cancers to form bone metastases is not completely understood; however, it undoubtedly involves a number of unique characteristics of both the tumor cells and the bone microenvironment. Such an explanation was proposed more than a decade ago with Paget’s “seed and soil” hypothesis, which suggested that meta-static cells are dispersed throughout the body, yet they will only survive and grow upon reaching tissues that are optimal for their growth (reviewed in ref. 1).

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Authors and Affiliations

  1. McMaster University/Juravinski Cancer Centre, Hamilton, Ontario, Canada

    Erin Giles BSc

  2. Department of Pathology and Molecular Medicine, Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada

    Gurmit Singh PhD

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  1. Erin Giles BSc
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Editors and Affiliations

  1. Department of Pathology and Molecular Medicine/Juravinski Cancer Centre, McMaster University, Hamilton, Ontario, Canada

    Gurmit Singh PhD

  2. Calcium Research Laboratory, McGill University Health Centre, Montreal, Quebec, Canada

    Shafaat A. Rabbani MD

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Giles, E., Singh, G. (2005). Role of TGF-β and IGF in Tumor Progression and Bone Metastases. In: Singh, G., Rabbani, S.A. (eds) Bone Metastasis. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59259-892-7:059

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  • DOI: https://doi.org/10.1385/1-59259-892-7:059

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