Abstract
Methods were earlier described (1) for the determination of proinflammatory mediators and biochemical markers, models of acute inflammation and pain (use of implanted sponges to study the acute inflammatory response, pleurisy and pouch models, and so on), models of nonarthritic inflammatory disorders and tissue injury (cutaneous models, eye models, models of acute pulmonary inflammation, animal models of inflammatory bowel disease, and so on), and animal models of arthritis (rat adjuvant arthritis, chronic remittent erosive arthritis, monoarticular antigen-induced arthritis, and cartilage proteoglycan-induced arthritis).
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References
Chang, J. Y. and Lewis, A. J., eds. (1989) Pharmacological Methods in the Control of Inflammation, Alan R. Liss, New York.
Morgan, D. W. and Marshall, L. A., eds. (1999) In Vivo Models of Inflammation, Birkhäuser Verlag, Basel, Boston, Berlin.
Gábor, M. (2000) Mouse Ear Inflammation Models and their Pharmacological Applications, Akadémiai Kiadó, Budapest, Hungary.
Gábor, M. and Rázga, Zs. (1992) Anti-oedematous effects of the H1-receptor antagonist dimethindene maleate. Agents Actions (Spec. Conf. Issue) C444–C447.
Blazsó, G. and Gábor, M. (1997) Evaluation of the anti-oedematous effects of some H1-receptor antagonists and methysergide in rats. Pharmacol. Res. 35, 65–71.
Blazsó, G., Rázga, Zs., and Gábor, M. (1999) Effects of cinnarizine on different experimentally induced oedemas. Fundam. Clin. Pharmacol. 13, 91–95.
Blazsó, G. and Gábor, M. (1994) Anti-oedematous action of some H1-receptor antagonists. Agents Actions 42, 13–18.
Procopiou, P. A., Biggadike, K., English, F. A., Farrel, R. M., et al. (2001) Novel glucocorticoid antedrugs possessing a 17β-(γ-lactone) ring. J. Med. Chem. 44, 602–612.
Young, J. M., Wagner, B. M., and Spires, D. A. (1983) Tachyphylaxis in 12-0-tetradecanoylphorbol acetate-and arachidonic-acid induced ear edema. J. Invest. Dermatol. 80, 48–52.
Young, J. M. and De Young, L. M. (1989) Cutaneous models of inflammation for the evaluation of topical and systemic pharmacological agents, in Pharmacological Methods in the Control of Inflammation (Chang J.Y. and Lewis, A.J., eds.), A.R. Liss, New York, pp. 215–231.
Swingle, K. F., Reiter, M. J., and Schwartzmiller, D. H. (1981) Comparison of croton oil and cantharidin-induced inflammations of the mouse ear and their modification by topically applied drugs. Arch. Int. Pharmacodyn. 254, 168–176.
Boris, A. and Hurley, J. F. (1977) Assessment of topical anti-inflammatory activity in rats with cantharidin-induced inflammation. J. Invest. Dermatol. 68, 161–164.
Inoue, H., Asaka, T., Nagata, N., and Koshihara, Y. (1997) Mechanism of mustard oil-induced skin inflammation in mice. Europ. J. Pharmacol. 333, 231–240.
Brattsand, R., Thalén, A., Roempke, K., Källström, L., and Gruvstad, E. (1982) Influence of 16α, 17α-acetal substitution and steroid nucleus fluorination on the topical to systemic activity ratio of glucocorticoids. J. Steroid. Biochem. 16, 779–786.
Gábor, M. and Rázga, Zs. (1990) Effects of non-steroidal antiphlogistics on mouse ear edema induced with dithranol. Acta Physiol. Acad. Sci. Hung. 75, 287–291.
Blazsó, G. and Gábor, M. (1995) Effects of prostaglandin antagonist phloretin derivatives on mouse ear edema induced with different skin irritants. Prostaglandins 50, 161–168.
Young, J. M., Spires, D. A., Bedord, C. J., Wagner, B., Ballaron, S. J., and De Young, L. M. (1984) The mouse ear inflammatory response to topical arachidonic acid. J. Invest. Dermatol. 82, 367–371.
Gábor, M. and Rázga, Zs. (1992) Development and inhibition of mouse ear edema induced with capsaicin. Agents Actions 36, 83–86.
Erdö, F., Török, K., Aráyi, P., and Székely, J. I. (1993) A new assay for antiphlogistic activity: Zymosan-induced mouse ear inflammation. Agents Actions 39, 137–142.
Tsuji, F., Miyake, Y., Enomoto, H., Horiuchi, M., and Mita, S. (1998) Effects of SA6541, a leukotriene A4 hydrolase inhibitor, and indomethacin on carrageenan-induced murine dermatitis. Europ. J. Pharmacol. 346, 81–85.
Huguet, A.-I., Recio, M. C., Manez, S., Giner, R.-M., and Rios, J.-L. (2000) Effect of triterpenoids on the inflammation induced by protein kinase C activators, neuronally active irritants and other agents. Europ. J. Pharmacol. 410, 69–81.
Viluksela, M. and Kosma, V.-M. (1991) Dithranol (anthralin)-induced skin irritation in C57BL/6, NMRI and SENCAR mice. Pharmacol. Toxicol. 69, 96–104.
Soliman, K. F. A., Soliman, M. R. J., Owasoyo, J. O., and Walker, C. A. (1983) Diurnal variation in the phlogogenic response of rats to inflammatory agents. J. Pharm. Pharmacol. 35, 388–389.
Labreque, G., Bureau, I.-P., and Reinberg, A. E. (1995) Biological rhytms in the inflammatory response and in the effects of non-steroidal anti-inflammatory drugs. Pharmac. Ther. 66, 285–300.
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Gábor, M. (2003). Models of Acute Inflammation in the Ear. In: Winyard, P.G., Willoughby, D.A. (eds) Inflammation Protocols. Methods in Molecular Biology, vol 225. Humana Press. https://doi.org/10.1385/1-59259-374-7:129
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DOI: https://doi.org/10.1385/1-59259-374-7:129
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