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Gene Therapy Approaches to Sensitization of Human Prostate Carcinoma to Cisplatin by Adenoviral Expression of p53 and by Antisense Jun Kinase Oligonucleotide Methods

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Genomics Protocols

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 175))

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Abstract

One of the challenges of medical research today is to find ways of bringing our genetic knowledge of cancer to clinical application and to develop improved therapies by exploiting gene-based strategies. By offering increased specificity and reduced toxicity, gene-based approaches promise alternatives when conventional treatments fail. Gene therapy also offers improved responses to conventional treatments when used in combination with gene therapy. Chief among the cancers in urgent need of improved treatment options is prostate cancer—the most commonly diagnosed cancer in men.

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Author information

Authors and Affiliations

  1. Sidney Kimmel Cancer Center, San Diego, CA

    Ruth Gjerset, Ali Haghighi, Svetlana Lebedeva & Dan Mercola

  2. Cancer Center, University of California at San Diego, La Jolla, CA

    Dan Mercola

Authors
  1. Ruth Gjerset
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  2. Ali Haghighi
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  3. Svetlana Lebedeva
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  4. Dan Mercola
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Editors and Affiliations

  1. UK Human Genome Mapping Project Resource Centre, Cambridge, UK

    Michael P. Starkey  & Ramnath Elaswarapu  & 

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© 2001 Humana Press Inc., Totowa, NJ

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Gjerset, R., Haghighi, A., Lebedeva, S., Mercola, D. (2001). Gene Therapy Approaches to Sensitization of Human Prostate Carcinoma to Cisplatin by Adenoviral Expression of p53 and by Antisense Jun Kinase Oligonucleotide Methods. In: Starkey, M.P., Elaswarapu, R. (eds) Genomics Protocols. Methods in Molecular Biology™, vol 175. Humana Press. https://doi.org/10.1385/1-59259-235-X:495

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  • DOI: https://doi.org/10.1385/1-59259-235-X:495

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-774-8

  • Online ISBN: 978-1-59259-235-7

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