Abstract
Rotavirus (RV) is a triple-protein-layered icosahedral virus, for which studies have established that the two outer-layer proteins, viral protein 4 (VP4) and viral protein 7 (VP7), are required for viral infectivity (1,2). VP7, a glycoprotein, is the major component of the outer-layer, but its role in viral entry is unclear. VP4 forms dimers extending out from the VP7-coated viral surface (3,4) and have been shown to be a determinant of host range and virulence, and is directly involved in cell attachment and RV entry into cells (5–8). Proteolytic cleavage of VP4 into two noncovalently associated subunits, VP8* and VP5* (2,9,10), significantly enhances viral infectivity (11–13).
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© 2000 Humana Press Inc., Totowa, NJ
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Gilbert, J.M., Greenberg, H.B. (2000). Rotavirus Entry into Tissue Culture Cells. In: Gray, J., Desselberger, U. (eds) Rotaviruses. Methods in Molecular Medicine™, vol 34. Humana Press. https://doi.org/10.1385/1-59259-078-0:67
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DOI: https://doi.org/10.1385/1-59259-078-0:67
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