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A triple entente: Virus, neurons, and CD8+ T cells maintain HSV-1 latency

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Abstract

Herpes simplex virus type 1 (HSV-1) travels by retrograde transport to sensory ganglia where latency is established. Recurrent disease results from virus reactivation and anterograde transport to nerve termini. Prevention of reactivation requires a complex interplay among virus, neuron, and immune response. Study of this tripartite relationship suggests possible interaction, and even communication among these components, that direct an immune response that allows for control of virus while preserving the viability of host tissue. Exciting new evidence supports the view that CD8+ effector T cells employ both lytic granule-dependent and interferon gamma-dependent effector mechanisms in maintaining HSV-1 latency.

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Author information

Author notes

  1. Robert L. Hendricks

    Present address: Department of Immunology, University of Pittsburgh, Pittsburgh, PA

Authors and Affiliations

  1. Graduate Program in Immunology, Magee-Womens Hospital, Pittsburgh, PA

    Sherrie Divito, Thomas L. Cherpes & Robert L. Hendricks

  2. Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital, Pittsburgh, PA

    Sherrie Divito, Thomas L. Cherpes & Robert L. Hendricks

  3. Department of Immunology, University of Pittsburgh, Pittsburgh, PA

    Sherrie Divito & Thomas L. Cherpes

  4. Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA

    Sherrie Divito, Thomas L. Cherpes & Robert L. Hendricks

  5. Department of Ophthalmology, University of Pittsburgh, 203 Lothrop Street, 15123, Pittsburgh, PA

    Sherrie Divito, Thomas L. Cherpes & Robert L. Hendricks

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  1. Sherrie Divito
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Divito, S., Cherpes, T.L. & Hendricks, R.L. A triple entente: Virus, neurons, and CD8+ T cells maintain HSV-1 latency. Immunol Res 36, 119–126 (2006). https://doi.org/10.1385/IR:36:1:119

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  • DOI: https://doi.org/10.1385/IR:36:1:119

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