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Zebrafish and cardiac toxicology

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Abstract

Model systems are a mainstay in toxicological research. Zebrafish are rapidly becoming an important model organism for studying vertebrate development. The advantages of zebrafish: short reproductive cycle, production of numerous transparent, synchronously developing embryos, low cost, and standardization make zebrafish and attractive model for toxicologists as well. The use of these fish to study heart development has moved forward very rapidly, laying the groundwork for studying the effects of chemicals on cardiac development and function. Here we describe approaches that can be used to study cardiac toxicity in developing zebrafish, focusing on examples where zebrafish embryos have been especially useful in understanding the impact of specific toxicants on heart development and function.

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Authors and Affiliations

  1. Molecular and Environmental Toxicology Center, University of Wisconsin, 777 Highland. Ave., 53705-2222, Madison, WI

    Warren Heideman, Dagmara S. Antkiewicz, Sara A. Carney & Richard E. Peterson

  2. School of Pharmacy, University of Wisconsin, 777 Highland Ave, 53705-2222, Madison, WI

    Warren Heideman & Richard E. Peterson

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  1. Warren Heideman
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Correspondence to Warren Heideman.

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Heideman, W., Antkiewicz, D.S., Carney, S.A. et al. Zebrafish and cardiac toxicology. Cardiovasc Toxicol 5, 203–214 (2005). https://doi.org/10.1385/CT:5:2:203

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