Liver: metabolic functions
FURTHER READING (2)
Metabolic regulation. A human perspective
(1996)Review of medical physiology
(1999)
Cited by (22)
Single-cell dynamics of liver development in postnatal pigs
2023, Science BulletinA GC–MS-based untargeted metabolomics approach for comprehensive metabolic profiling of vancomycin-induced toxicity in mice
2022, HeliyonCitation Excerpt :Therefore, it was speculated that VCM administration induced a redox imbalance in the liver, kidney, and cerebral cortex. As amino acids are mainly metabolized in the liver [24], the dysregulations of alanine, aspartate and glutamate metabolism, arginine and proline metabolism, arginine biosynthesis, glycine serine and threonine metabolism, and phenylalanine, tyrosine and tryptophan biosynthesis may lead to liver injury in this study. In addition, liver dysfunction induced the urea synthesis disrupted, resulting in elevated urea in the liver and lung.
Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
2021, Cell ReportsCitation Excerpt :Despite the importance of metabolic reprogramming in cancer development, only a handful of molecular inhibitors targeting metabolic aberrations in cancer have attained satisfactory outcomes in clinical trials and have been approved by the FDA for clinical use (Mullard, 2017; Liu et al., 2020). The liver is one of the most metabolically active organs in our body and has critical roles in regulating different metabolic processes (Campbell, 2006). Emerging evidence suggests that metabolic reprogramming of glucose, glutamine, and fatty acids contributes to HCC development and progression (Zhu et al., 2020).
Involvement of endocannabinoid system, inflammation and apoptosis in diabetes induced liver injury: Role of 5-HT3 receptor antagonist
2020, International ImmunopharmacologyCitation Excerpt :It is a modifiable risk factor affecting the development of organ damage including liver disease [2] which is manifested by hepatomegaly, abdominal pain, and elevated serum levels of aspartate transaminase (AST), and alanine transaminase (ALT) activities [3]. The liver is the major metabolic organ whose role in regulating carbohydrate, fat, and protein metabolism has been established [4]. Increasing evidence suggests that oxidative stress and subsequent inflammation play a major role in liver damage of diabetic condition [5].
A histomorphometric study on the hepatoprotective effects of a green rooibos extract in a diet-induced obese rat model
2019, Acta HistochemicaCitation Excerpt :In obesity, the influx of dietary carbohydrates and fat may lead to increased oxidative stress resulting in significant strain on glucose and lipid balance maintained by the liver (Hanhineva et al., 2010). The liver plays a major role in glucose homeostasis and storage (via glycogenesis) as well as glucose secretion (via glycogenolysis and gluconeogenesis); (Campbell, 2006; Hanhineva et al., 2010). Glucose balance is controlled by insulin, however, excess glucose (hyperglycaemia) and the development of peripheral insulin resistance leads to hyperinsulinemia.
Distinguishing metabolic signals of liver tumors from surrounding liver cells using hyperpolarized <sup>13</sup>C MRI and gadoxetate
2024, Magnetic Resonance in Medicine