Chest
Selected ReportsEndocarditis due to Strain of Cardiobacterium hominis Resistant to Erythromycin and Vancomycin
Section snippets
Case Report
A 47-year-old woman who had been in good health noted the gradual onset of fatigue, night sweats, and loss of weight six months before admission. Three years previously, a Starr-Edwards mitral valve prosthesis and a transvenous demand pacemaker were inserted because of atrial flutter with high-degree atrioventricular block and rheumatic mitral stenosis. Two months before the onset of symptoms, extractions of carious teeth were performed on three occasions. Because of a history of an allergy to
Discussion
The minimal inhibitory concentrations (MICs) of erythromycin, vancomycin, penicillin G, tetracycline, cephalexin, and cefaclor were determined using a microdilution broth technique with trypticase soy broth (BBL) and a final inoculum of 105 to 106 colonyforming units of the C hominis per milliliter. After 48 hours of incubation at 37°C in 5 percent carbon dioxide, the values for MIC were read as the lowest concentration of drug that inhibited visible growth. The minimal bactericidal
ACKNOWLEDGMENT
We thank Ms. Jean Barnishan and Ms. Lisa Stone for expert technical assistance.
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