Chest
Clinical InvestigationsSleep and BreathingSymptomatic Gastroesophageal Reflux in Subjects With a Breathing Sleep Disorder
Section snippets
Materials and Methods
The reflux questionnaire was administered to 271 consecutive and previously untreated patients with a suspected breathing sleep disorder, referred for sleep studies between October 1998 and April 2000 just before their initial sleep study. The GERQ was a self-reported instrument designed to measure symptoms experienced during the last year, and was comprised of 80 questions as well as a psychosomatic symptom checklist for a measure of somatization. The first section (30 questions) inquired into
Results
Of 271 eligible participants, 228 subjects (84%) were included in the analysis. Of the other 43 participants, 24 subjects did not complete the questionnaire, 12 subjects were unable to speak or read English, 6 subjects refused to participate, and 1 subject was mentally handicapped. Anthropometric data and results of the sleep investigations for the 228 eligible participants with complete information are shown in Table 1. The 4% Sao2 dip rate, body mass index, Epworth sleepiness scale score, and
Discussion
We have shown that GER is common in subjects with a breathing sleep disorder. Typical symptoms include heartburn and acid regurgitation, which were intermittently noted by almost 60% of the respondents, of which 23% reported frequent (at least weekly) episodes of GER. A subset of patients presented with atypical symptoms, and we observed a high prevalence of potential risk factors for GER and self-reported comorbidity, with hypertension and cardiovascular disease reported more frequently in
ACKNOWLEDGMENT
We thank K.Y. Wong and A.D. McGown for their help in data collection.
References (33)
- et al.
Symptoms in gastro-oesophageal reflux disease
Lancet
(1990) - et al.
Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota
Gastroenterology
(1997) - et al.
Nasal CPAP reduces gastroesophageal reflux in obstructive sleep apnea syndrome
Chest
(1992) - et al.
A new questionnaire for gastroesophageal reflux disease
Mayo Clin Proc
(1994) - et al.
Increased prevalence of gastroesophageal reflux symptoms in patients with COPD
Chest
(2001) - et al.
The oesophagus as a cause of recurrent chest pain: which patients should be investigated and which tests should be used?
Lancet
(1985) - et al.
Identification and mechanism of delayed esophageal acid clearance in subjects with hiatus hernia
Gastroenterology
(1987) - et al.
Health-related quality of life and severity of symptoms in patients with Barrett's esophagus and gastroesophageal reflux disease patients without Barrett's esophagus
Am J Gastroenterol
(2000) Sleep related breathing disorders in adults
Sleep
(1999)- et al.
A community study of snoring and sleep disordered breathing
Am J Respir Crit Care Med
(1995)
Gastroesophageal reflux disease
Clin Rev
The prevalence of symptoms suggestive of esophageal disorders
Scand J Gastroenterol
Symptomatic gastroesophageal reflux: incidence and precipitating factors
Am J Dig Dis
Epidemiology of esophageal and supraesophageal reflux injuries
Am J Med
Daytime sleepiness, snoring and gastro-oesophageal reflux amongst young adults in three European countries
J Intern Med
Gastroesophageal reflux and obstructive sleep apnea
Sleep
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