Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients
Fig 2
Comparison of human and mouse FosB proteins.
(A) Western blot of hippocampal proteins with FosB antibody reveals multiple additional bands in typical human cocaine addict HPC sample compared to a chronic cocaine-treated (15 mg/kg for 7 days) mouse HPC. Novel bands are apparent at 20 kDa, 23 kDa (white arrow), and 30 kDa (black arrow). (B) Correlation and linear regression plots of protein expression for each band in the human samples with the postmortem interval (time between death and brain freezing) for each human sample. Dotted lines represent 95% confidence interval; no linear regression slope differed significantly from 0.