Prolonged High Fat Diet Reduces Dopamine Reuptake without Altering DAT Gene Expression
Figure 4
Six weeks of high fat diet reduces the rate of dopamine reuptake and attenuates the dopamine response to cocaine.
Average peak dopamine concentration evoked by VTA/SNpc stimulation following either 2 (a) or 6 weeks (b) of diet exposure before cocaine injection. c–d) Average Tau following 2 (c) wks or 6 wks (d) of diet exposure. Tau was significantly greater for HFD-6 wk rats relative to LFD-6 wk rats (*p<0.05). e–f) Percent change in peak evoked dopamine concentration after cocaine injection for 2 (e) and 6 (f) weeks of diet exposure. Percent change was significantly smaller in HFD-6 wk relative to LFD-6 wk rats (**p<0.01).