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Publicly Available Published by De Gruyter June 12, 2011

Desired properties of new phthalocyanines for photodynamic therapy

  • Tebello Nyokong

The manuscript focuses on the properties of phthalocyanines (Pcs) that are required for them to be employed as photosensitizers in applications such as photodynamic therapy (PDT). High triplet-state quantum yields and lifetimes as well as high singlet-oxygen quantum yields are required for a good photosensitizer. In addition, absorption of the photosensitizer in the red region of the electromagnetic spectrum is also required, and this can be achieved by ring expansion, substitution with electron-donating ligands, and change of the central metal among others. Quantum dots (QDs) are efficient accumulators of light energy, and they can transfer this energy to molecules that possess a very efficient ability to generate singlet oxygen through a process called Förster resonance energy transfer (FRET). Thus, there is a decrease in the fluorescence quantum yield of the QDs when in the vicinity of Pcs. Triplet quantum yields of the Pcs increase in the presence of QDs.

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Conference

Eurasia Conference on Chemical Sciences, 11th, The Dead Sea, Jordan, 2010-10-06–2010-10-10


Online erschienen: 2011-6-12
Erschienen im Druck: 2011-6-12

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