Lithiated alkoxyallenes are very versatile components for the synthesis of heterocycles such as furans, pyrroles, and 1,2-oxazines, easily allowing the preparation of natural products via these heterocyclic intermediates. A surprising three-component synthesis of N-acylated enaminones allowed the synthesis of highly functionalized 4-hydroxypyridines, 5-acetyloxazoles, and pyrimidines. All these heterocyclic products are ready for further functionalizations, in particular for palladium-catalyzed reactions, leading to libraries of new interesting heterocycles.
Conference
International Congress on Heterocyclic Chemistry (ICHC-22), International Congress on Heterocyclic Chemistry, ICHC, Heterocyclic Chemistry, 22nd, St John's, Newfoundland and Labrador, Canada, 2009-08-02–2009-08-07
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