A method for predicting fracture toughness of a given laminate of any stacking sequence on the basis of the fracture toughness values of the constituent unidirectional plies is proposed. The laminate toughness prediction method is combined with a finite fracture mechanics (FFM) model to predict the notched strengths of two kinds of quasi-isotropic laminates. Static tension tests are first carried out on specimens with a circular open hole for four different values of hole-diameter to specimen-width ratios, respectively. The quasi-isotropic laminates of different stacking sequences exhibited similar notch sensitivity. Slightly smaller values of notched strength were predicted using the FFM model predicted with the ply-based laminate fracture toughness prediction method, regardless of notch size.