Hyperandrogenism correlates with psychological symptoms in adolescents with          polycystic ovary syndrome

Zeynep Donbaloğlu; Hale Tuhan; Özge Gizli Çoban; Deniz Özalp Kızılay; Eren İsmailoğlu; Arif Önder; Sezer Acar; Aynur Bedel; Ebru Barsal Çetiner; Berna Singin; Harun Erdem; Mesut Parlak

doi:10.1297/cpe.2022-0010

Original Article

Hyperandrogenism correlates with psychological symptoms in adolescents with polycystic ovary syndrome

Zeynep Donbaloğlu, Hale Tuhan, Özge Gizli Çoban, Deniz Özalp Kızılay, Eren İsmailoğlu, Arif Önder, Sezer Acar, Aynur Bedel, Ebru Barsal Çetiner, Berna Singin, Harun Erdem, Mesut Parlak

Author information

Zeynep Donbaloğlu
Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkey
Hale Tuhan
Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkey
Özge Gizli Çoban
Department of Child and Adolescent Psychiatry, Akdeniz University Hospital, Antalya, Turkey
Deniz Özalp Kızılay
Department of Pediatric Endocrinology, Bakırçay University Çiğli Training and Research Hospital, Izmir, Turkey
Eren İsmailoğlu
Department of Radiology, Bakırçay University Çiğli Training and Research Hospital, Izmir, Turkey
Arif Önder
Department of Child and Adolescent Psychiatry, Akdeniz University Hospital, Antalya, Turkey
Sezer Acar
Department of Pediatric Endocrinology, Behçet Uz Children Hospital, İzmir, Turkey
Aynur Bedel
Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkey
Ebru Barsal Çetiner
Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkey
Berna Singin
Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkey
Harun Erdem
Department of Child and Adolescent Psychiatry, Bakırçay University Çiğli Training and Research Hospital, Izmir, Turkey
Mesut Parlak
Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkey

Keywords: Polycystic ovary syndrome, adolescent, psychological well-being, depression, hyperandrogenism

JOURNAL OPEN ACCESS

2022 Volume 31 Issue 2 Pages 68-76

DOI https://doi.org/10.1297/cpe.2022-0010

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Abstract

This study aimed to analyze the depressive and anxiety states of adolescent girls with polycystic ovary syndrome (PCOS). This was a cross-sectional, multicenter, case–control study. A total of 100 participants (PCOS group, 51; control group, 49) aged 13–18 yr were included in the study. Body mass index was higher in patients with PCOS (P = 0.002). In the PCOS group, 28.5% of the patients had moderate-to-severe depressive symptoms, whereas the incidence was lower in controls (8.3%, P = 0.021). The State-Trait Anxiety Inventory (STAI)-State, STAI-Trait, and physical, psychosocial, and total Pediatric Quality of Life Inventory PedsQL scores were higher in the PCOS group, suggesting that anxiety was more common and the quality of life was worse in patients with PCOS than in healthy participants (P = 0.01, P = 0.03, P = 0.02, P = 0.046, and P = 0.047, respectively). The serum free testosterone (fT) levels were positively correlated with the depression and anxiety scores and negatively correlated with the psychosocial PedsQL scores. In conclusion, adolescent girls diagnosed with PCOS demonstrated higher depressive and anxiety symptoms and lower psychosocial quality of life scores than their healthy counterparts. A relationship was found between the fT level and all psychological measures.

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