Relationships among fecal daidzein metabolites, dietary habit and BMI in healthy volunteers: a preliminary study

Motoi TAMURA; Sachiko HORI; Hiroyuki NAKAGAWA; Kazuhiro KATADA; Kazuhiro KAMADA; Kazuhiko UCHIYAMA; Osamu HANDA; Tomohisa TAKAGI; Yuji NAITO; Toshikazu YOSHIKAWA

doi:10.12938/bmfh.2014-019

Note

Relationships among fecal daidzein metabolites, dietary habit and BMI in healthy volunteers: a preliminary study

Motoi TAMURA, Sachiko HORI, Hiroyuki NAKAGAWA, Kazuhiro KATADA, Kazuhiro KAMADA, Kazuhiko UCHIYAMA, Osamu HANDA, Tomohisa TAKAGI, Yuji NAITO, Toshikazu YOSHIKAWA

Author information

Motoi TAMURA
National Food Research Institute of the National Agriculture and Food Research Organization, 2-1-12, Kannondai, Tsukuba, Ibaraki 305-8642, Japan
Sachiko HORI
National Food Research Institute of the National Agriculture and Food Research Organization, 2-1-12, Kannondai, Tsukuba, Ibaraki 305-8642, Japan
Hiroyuki NAKAGAWA
National Food Research Institute of the National Agriculture and Food Research Organization, 2-1-12, Kannondai, Tsukuba, Ibaraki 305-8642, Japan
Kazuhiro KATADA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachidori Hirokojiagaru, Kamigyo-ku, Kyoto 602-8566, Japan
Kazuhiro KAMADA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachidori Hirokojiagaru, Kamigyo-ku, Kyoto 602-8566, Japan
Kazuhiko UCHIYAMA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachidori Hirokojiagaru, Kamigyo-ku, Kyoto 602-8566, Japan
Osamu HANDA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachidori Hirokojiagaru, Kamigyo-ku, Kyoto 602-8566, Japan
Tomohisa TAKAGI
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachidori Hirokojiagaru, Kamigyo-ku, Kyoto 602-8566, Japan
Yuji NAITO
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachidori Hirokojiagaru, Kamigyo-ku, Kyoto 602-8566, Japan
Toshikazu YOSHIKAWA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachidori Hirokojiagaru, Kamigyo-ku, Kyoto 602-8566, Japan

Keywords: daidzein, dihydrodaidzein, equol, microbiota

JOURNAL FREE ACCESS

2015 Volume 34 Issue 3 Pages 59-65

DOI https://doi.org/10.12938/bmfh.2014-019

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Abstract

To investigate the relationships among fecal isoflavone metabolism, dietary habit and Body Mass Index (BMI), 15 healthy men and 15 healthy women were recruited and provided stool samples for analysis of ex vivo anaerobic incubation of fecal suspension with daidzein. A negative correlation was observed between BMI and the dihydrodaidzein (DHD) production in men, and between BMI and the equol production in women. There was a positive correlation between intake of soluble dietary fiber and the DHD production in men. The results suggest that dietary habits and BMI are related to the metabolic activity of isoflavonoids by fecal intestinal microbiota.

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