Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198
Case Reports
Malignant Mesothelioma in the Thoracic Cavity of a Crj:CD(SD) Rat Characterized by Round Hyalinous Stroma
Takuya Doi, Yuri Kotani, Kazuaki Takahashi, Satomi Hashimoto, Naoaki Yamada, Hiroko Kokoshima, Yuki Tomonari, Yumi Wako, Minoru Tsuchitani
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Keywords: mesothelioma, round hyalinous stroma, thoracic cavity, spontaneous, Crj:CD(SD) rat
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2010 Volume 23 Issue 2 Pages 103-106

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Abstract

Spontaneous malignant mesothelioma was found in a 104-week-old male Crj:CD(SD) rat. The tumor was scattered on the surface of the lung, heart, mediastinal pleura and thoracic wall and metastasized to the alveolar septa. Histopathologically, small flattened or cuboidal tumor cells proliferated with stroma, formed almost normal papillary structures and reacted positively to colloidal iron stain and immunohistochemical staining for mesothelin. Round hyalinous stromata were pronounced, which is a characteristic feature, and the possible reason for this is as follows; at first, a small amount of collagen fibers was formed in the center of the clusters of several tumor cells, and then the cell clusters expanded like balloons with an increase in the collagen fibers.

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© 2010 The Japanese Society of Toxicologic Pathology
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