Inoculation of Fusobacterium necrophorum into the portal venous system of cattle resulted in the formation of microabscesses and disseminated microthrombi in the liver. The microabscesses expanded with multiplication of F. necrophorum, resulting in the formation of coagulative necrosis. The areas were encapsulated with granulation tissues. The development of hepatic lesions was partially associated with intravascular coagulation in the liver.