Identification and Sequence Analysis of the Marek’s Disease Virus Serotype 2 Homologous Genes of the Herpes Simplex Virus Type 1 UL25, UL26 and UL26.5 Genes

Kentaro KATO; yung-Kwan HJANG; Yoshihiro IZUMIYA; Jin-Shun CAI; Yoshinori TSUSHIMA; Takayuki MIYAZAWA; Chieko KAI; Takeshi MIKAMI

doi:10.1292/jvms.61.787

Kentaro KATO, yung-Kwan HJANG, Yoshihiro IZUMIYA, Jin-Shun CAI, Yoshinori TSUSHIMA, Takayuki MIYAZAWA, Chieko KAI, Takeshi MIKAMI

Author information

Kentaro KATO
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
yung-Kwan HJANG
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Yoshihiro IZUMIYA
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Jin-Shun CAI
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Yoshinori TSUSHIMA
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Takayuki MIYAZAWA
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Chieko KAI
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Takeshi MIKAMI
The Research Center for Protozoan Molecular Immunology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan

Keywords: Marek’s disease virus serotype 2, transcript, UL25, UL26, UL26.5

JOURNAL FREE ACCESS

1999 Volume 61 Issue 7 Pages 787-793

DOI https://doi.org/10.1292/jvms.61.787

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Abstract

We identified and determined the nucleotide sequence of Marek’s disease virus serotype 2 (MDV2) UL25, UL26 and UL26.5 homologous genes of herpes simplex virus type 1 (HSV-1). The UL25, UL26 and UL26.5 genes of HSV-1 encode virion proteins (UL25 and UL26.5) and serine protease (UL26). The deduced amino acid sequences of the three proteins show a high degree of homology to counterparts of HSV-1. By northern blot analyses we found that four transcripts whose sizes are 4.9, 3.9, 2.0 and 1.3 kb are transcribed from the domains of MDV2 genome containing the three genes. This is the first report dealing with UL25, UL26 and UL26.5 homologues of HSV-1 in MDV serotypes.

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