Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects          dopaminergic neurons and causes hyperactivity in male mice

Naoki YONEDA; Tadashi TAKADA; Tetsushi HIRANO; Shogo YANAI; Anzu YAMAMOTO; Youhei MANTANI; Toshifumi YOKOYAMA; Hiroshi KITAGAWA; Yoshiaki TABUCHI; Nobuhiko HOSHI

doi:10.1292/jvms.18-0014

Toxicology

Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice

Naoki YONEDA, Tadashi TAKADA, Tetsushi HIRANO, Shogo YANAI, Anzu YAMAMOTO, Youhei MANTANI, Toshifumi YOKOYAMA, Hiroshi KITAGAWA, Yoshiaki TABUCHI, Nobuhiko HOSHI

Author information

Naoki YONEDA
Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada, Kobe, Hyogo 657-8501, Japan
Tadashi TAKADA
Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada, Kobe, Hyogo 657-8501, Japan
Tetsushi HIRANO
Division of Drug and Structural Research, Life Science Research Center, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
Shogo YANAI
Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada, Kobe, Hyogo 657-8501, Japan
Anzu YAMAMOTO
Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada, Kobe, Hyogo 657-8501, Japan
Youhei MANTANI
Laboratory of Histophysiology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada, Kobe, Hyogo 657-8501, Japan
Toshifumi YOKOYAMA
Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada, Kobe, Hyogo 657-8501, Japan
Hiroshi KITAGAWA
Laboratory of Histophysiology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada, Kobe, Hyogo 657-8501, Japan
Yoshiaki TABUCHI
Division of Molecular Genetics Research, Life Science Research Center, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
Nobuhiko HOSHI
Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada, Kobe, Hyogo 657-8501, Japan

Keywords: dinotefuran, dopamine, hyperactivity, neonicotinoid, neurobehavioral effect

JOURNAL FREE ACCESS

2018 Volume 80 Issue 4 Pages 634-637

DOI https://doi.org/10.1292/jvms.18-0014

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Abstract

Although neonicotinoid pesticides are expected to have harmful influence on mammals, there is little animal experimental data to support the effect and mechanisms. Since acetylcholine causes the release of dopamine, neonicotinoids may confer a risk of developmental disorders via a disturbance in the monoamine systems. Male mice were peripubertally administered dinotefuran (DIN) referring to no observed effect level (NOEL) and performed behavioral and immunohistological analyses. In an open field test, the total locomotor activity was increased in a dose-dependent manner. The immunoreactivity of tyrosine hydroxylase in the substantia nigra was increased in DIN-exposed mice. These results suggest that exposure to DIN in peripubertal male mice causes hyperactivity and a disturbance of dopaminergic signaling.

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