Small Cell Lung Cancer with Sarcoidosis in Spontaneous Remission: A Case Report

Yumeka Sasaki; Yasuhiko Koga; Norimitsu Kasahara; Yoshimasa Hachisu; Keisuke Murata; Hiroaki Tsurumaki; Masakiyo Yatomi; Yusuke Tsukagoshi; Yuri Sawada; Reiko Sakurai; Akihiro Ono; Noriaki Sunaga; Kyoichi Kaira; Junko Hirato; Toshitaka Maeno; Kunio Dobashi; Takeshi Hisada

doi:10.1272/jnms.JNMS.2018_85-47

Case Reports

Small Cell Lung Cancer with Sarcoidosis in Spontaneous Remission: A Case Report

Yumeka Sasaki, Yasuhiko Koga, Norimitsu Kasahara, Yoshimasa Hachisu, Keisuke Murata, Hiroaki Tsurumaki, Masakiyo Yatomi, Yusuke Tsukagoshi, Yuri Sawada, Reiko Sakurai, Akihiro Ono, Noriaki Sunaga, Kyoichi Kaira, Junko Hirato, Toshitaka Maeno, Kunio Dobashi, Takeshi Hisada

Author information

Yumeka Sasaki
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Yasuhiko Koga
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Norimitsu Kasahara
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Yoshimasa Hachisu
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Keisuke Murata
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Hiroaki Tsurumaki
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Masakiyo Yatomi
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Yusuke Tsukagoshi
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Yuri Sawada
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Reiko Sakurai
Oncology Center, Gunma University Graduate School of Medicine
Akihiro Ono
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Noriaki Sunaga
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Kyoichi Kaira
Department of Oncology Clinical Development, Gunma University Graduate School of Medicine
Junko Hirato
Department of Pathology, Gunma University Hospital
Toshitaka Maeno
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine
Kunio Dobashi
Gunma University Graduate School of Health Sciences
Takeshi Hisada
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine

Keywords: sarcoidosis, small cell lung cancer, checkpoint inhibitor, ipilimumab, amrubicin

JOURNAL FREE ACCESS

2018 Volume 85 Issue 5 Pages 291-296

DOI https://doi.org/10.1272/jnms.JNMS.2018_85-47

Details

Abstract

A 69-year-old woman was diagnosed with sarcoidosis, which was not treated with corticosteroid therapy. Her levels of angiotensin converting enzyme decreased significantly over 4 years and a mass lesion was detected near the lower part of her left main bronchus, and diagnosed as small cell lung cancer (SCLC). Treatment of the SCLC with a series of chemotherapeutic agents produced excellent results. The pulmonary sarcoidosis did not show any deterioration despite the frequent use of amrubicin, which is known to be a cause of interstitial pneumonia. This is a case report of SCLC complicated with sarcoidosis in a stage of spontaneous remission, possibly suggesting an association between sarcoidosis and tumor immunity, since recent reports have suggested that immune checkpoint inhibitors might be involved in the development of sarcoidosis.

Corresponding author

Register with J-STAGE for free!