Frequencies of polyhaploid production were compared among three hexaploid wheat varieties (2u = 6x = 42, Chinese Spring, Norin 61 and Siete Cerros) pollinated with maize, pearl millet and sorghum lines. All wheat varieties produced embryos in crosses with maize lines at frequencies ranging from 12.6 to 26.8 % . In crosses with pearl millet lines, the embryo formation frequencies were affected by both the wheat varieties and pearl millet lines. In crosses with sorghum lines, the frequencies were highly dependent on the wheat varieties and Siete Cerros produced no embryos. Embryos were obtained from Chinese Spring and Norin 61 in crosses with all lines of maize, pearl millet and sorghum. The embryos from crosses with maize were larger, but developed into plants at lower frequencies than those from crosses with pearl millet and sorghum. Most of the 377 plants cytologically examined were wheat polyhaploids that carried a complement of 3 x = 21 chromosomes. It is inferred that maize-mediated polyhaploid production is more stable than those mediated by pearl millet and sorghum because of less genotypic effects on embryo formation