22 October 2015 : Hypothesis
Epigallocatechin-3-Gallate Reduces Cytotoxic Effects Caused by Dental Monomers: A Hypothesis
Yang JiaoBCDEF, Sai MaAG, Yirong WangEF, Jing LiBCDF, Lequn ShanBG, Jihua ChenAGDOI: 10.12659/MSM.895628
Med Sci Monit 2015; 21:3197-3202
Abstract
Resin monomers from dental composite materials leached due to incomplete polymerization or biodegradation may cause contact allergies and damage dental pulp. The cytotoxicity of dental resin monomers is due to a disturbance of intracellular redox equilibrium, characterized by an overproduction of reactive oxygen species (ROS) and depletion of reduced glutathione (GSH). Oxidative stress caused by dental resin monomers leads to the disturbance of vital cell functions and induction of cell apoptosis in affected cells. The nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway plays a key role in the cellular defense system against oxidative and electrophilic stress. Epigallocatechin-3-gallate (EGCG) can activate the Nrf2 pathway and induce expression of a multitude of antioxidants and phase II enzymes that can restore redox homeostasis. Therefore, here, we tested the hypothesis that EGCG-mediated protection against resin monomer cytotoxicity is mediated by activation of the Nrf2 pathway. This study will help to elucidate the mechanism of resin monomer cytotoxicity and provide information that will be helpful in improving the biocompatibility of dental resin materials.
Keywords: Antioxidants - metabolism, Biocompatible Materials, Catechin - chemistry, Dental Pulp - drug effects, Dogs, Glutathione - chemistry, Mice, Knockout, NF-E2-Related Factor 2 - metabolism, Oxidation-Reduction, Phenotype, Reactive Oxygen Species - metabolism, Resins, Synthetic - toxicity, Tooth - drug effects
Editorial
01 June 2024 : Editorial
Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other MammalsDOI: 10.12659/MSM.945315
Med Sci Monit 2024; 30:e945315
In Press
Database Analysis
Enhanced Sweat Biosensing with Thread-Embedded Microfluidic DevicesMed Sci Monit In Press; DOI: 10.12659/MSM.943321
Database Analysis
Comparative Cardiovascular Risks of Febuxostat and Allopurinol in Patients with Diabetes Mellitus and Chron...Med Sci Monit In Press; DOI: 10.12659/MSM.944314
Clinical Research
Trust and Support for Cancer Research Biobanks: Insights from Cancer Patients in PolandMed Sci Monit In Press; DOI: 10.12659/MSM.944263
Clinical Research
Morphological and Dimensional Analysis of the Nasopalatine Canal: Insights from Cone-Beam Computed Tomograp...Med Sci Monit In Press; DOI: 10.12659/MSM.944424
Most Viewed Current Articles
14 Dec 2022 : Clinical Research 1,404,022
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
17 Jan 2024 : Review article 1,343,206
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research 690,039
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial 50,065
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952