Regulatory Pathways Controlling the Endovascular Invasive Trophoblast Cell Lineage

Michael J. SOARES; Damayanti CHAKRABORTY; Stephen J. RENAUD; Kaiyu KUBOTA; Pengli BU; Toshihiro KONNO; M.A. Karim RUMI

doi:10.1262/jrd.2011-039

Reviews

Regulatory Pathways Controlling the Endovascular Invasive Trophoblast Cell Lineage

Michael J. SOARES, Damayanti CHAKRABORTY, Stephen J. RENAUD, Kaiyu KUBOTA, Pengli BU, Toshihiro KONNO, M.A. Karim RUMI

Author information

Michael J. SOARES
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas 66160, USA
Damayanti CHAKRABORTY
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas 66160, USA
Stephen J. RENAUD
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas 66160, USA
Kaiyu KUBOTA
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas 66160, USA
Pengli BU
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas 66160, USA
Toshihiro KONNO
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas 66160, USA
Present: Laboratory of Animal Breeding, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo 113-8657, Japan
M.A. Karim RUMI
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas 66160, USA

Keywords: Activator protein 1, AKT, FOS like antigen 1, Hypoxia, Hypoxia inducible factor, Phosphatidylinositol 3-kinase, Placentation, Pregnancy, Trophoblast invasion

JOURNAL FREE ACCESS

2012 Volume 58 Issue 3 Pages 283-287

DOI https://doi.org/10.1262/jrd.2011-039

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Abstract

Hemochorial placentation is characterized by trophoblast-directed uterine spiral artery remodeling. The rat and human both possess hemochorial placentation and exhibit remarkable similarities regarding the depth of trophoblast invasion and the extent of uterine vascular modification. In vitro and in vivo research methodologies have been established using the rat as an animal model to investigate the extravillous/invasive trophoblast lineage. With these research approaches, two signaling pathways controlling the differentiation and invasion of the trophoblast cell lineage have been identified: i) hypoxia/hypoxia inducible factor and ii) phosphatidylinositol 3-kinase/AKT/Fos like antigen 1. Dissection of these pathways has facilitated identification of fundamental regulators of the invasive trophoblast cell lineage.

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