The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

  1. Ana Eulalio,
  2. Felix Tritschler and
  3. Elisa Izaurralde
  1. Department of Biochemistry, Max Planck Institute for Developmental Biology, D-72076 Tübingen, Germany

    Abstract

    GW182 family proteins interact directly with Argonaute proteins and are required for miRNA-mediated gene silencing in animal cells. The domains of the GW182 proteins have recently been studied to determine their role in silencing. These studies revealed that the middle and C-terminal regions function as an autonomous domain with a repressive function that is independent of both the interaction with Argonaute proteins and of P-body localization. Such findings reinforce the idea that GW182 proteins are key components of miRNA repressor complexes in metazoa.

    Keywords

    Footnotes

    • Reprint requests to: Elisa Izaurralde, Department of Biochemistry, Max Planck Institute for Developmental Biology, Spemannstrasse 35, D-72076 Tübingen, Germany; e-mail: elisa.izaurralde{at}tuebingen.mpg.de; fax: 49-7071-601-1353.

    • Article published online ahead of print. Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.1703809.

    • Freely available online through the RNA Open Access option.

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    This Article

    1. Published in Advance June 17, 2009, doi: 10.1261/rna.1703809 RNA 15: 1433-1442 Copyright © 2009 RNA Society

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